Cytotoxic T lymphocyte (CTL)-induced programmed cell deaths, including apoptosis and necroptosis, occur in skin diseases such as graft versus host disease (GVHD) severe drug eruptions. It has been reported that Fas-FasL, perforin, granzyme B induce these tumor necrosis factor-α (TNF-α) signaling is involved necroptosis. However, the molecular mechanisms of TNF-α deaths induced by CTLs have yet ...