Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer’s disease. This results a low-noradrenergic state some patients, which contributes to cognitive and neuropsychi- atric symptoms. We aimed assess efficacy noradrenergic drugs for improving these Methods The MEDLINE, Embase, ClinicalTrials.gov databases were searched from 1980 December 2021. generated poo...
