In the management of metastatic breast cancer, fewer recognized therapeutic standards are available as compared to the early stages of the disease. Thus, it is pertinent to search for new, effective therapy to improve survival, tolerability and quality of life of patients. In this study, a liposomal formulation was developed for a novel dihydrofolate reductase (DHFR) inhibitor, M-V-05. Drug enc...

The perennial stoloniferous herbaceous vine Mikania micrantha H.B.K. is among the most noxious exotic invaders in China and the world. Disturbance can fragment stolons of M. micrantha and disperse these fragments over long distances or bury them in soils at different depths. To test their regeneration capacity, single-node stolon fragments with stolon internode lengths of 0, 3, 6 and 12 cm were...

Gold electrodes disks (2.0 mm diameter, Metrohm) were mechanically polished with aluminum oxide pads or diamond spray on polishing cloth (Kemet) of progressively decreasing particle size: 1 μm, 0.3 μm and 0.05 μm, with intermittent sonication in water. The electrodes were then electrochemically polished in a deaerated NaOH or KOH 0.5 mol L between the potentials -1.5 V and -0.5 V vs. Ag|AgCl or...

The ground water denitrification capacity of riparian zones in deep soils, where substantial ground water can flow through low-gradient stratified sediments, may affect watershed nitrogen export. We hypothesized that the vertical pattern of ground water denitrification in riparian hydric soils varies with geomorphic setting and follows expected subsurface carbon distribution (i.e., abrupt decli...

The hot Jupiter HD 189733bwas observed during its primary transit using the InfraredArray Camera on the Spitzer Space Telescope. The transit depths were measured simultaneously at 3.6 and 5.8 m. Our analysis yields values of 2:356% 0:019% and 2:436% 0:020% at 3.6 and 5.8 m, respectively, for a uniform source. We estimated the contribution of the limb-darkening and starspot effects on the final ...