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After early microbicide candidates failed in clinical trials to prevent HIV, recent news from the South African CAPRISA-004 study suggest that the new generation of vaginal microbicide gels using antiretroviral drugs like tenofovir could be effective and reduce HIV and herpes simplex virus (HSV)-2 acquisition.1 This landmark study greatly energized the field and revived enthusiasm for the devel...
Introduction Monosodium urate (MSU) crystal induced interleukin-1 (IL-1b) secretion is a critical pathogenic factor in the development of gout and serves as therapeutic target in these patients. Nevertheless, without co-stimulation by a pro-IL-1ß inducing factor, e.g. lipopolysaccharides (LPS), MSU alone cannot induce IL-1b secretion in vitro. The endogenous Toll-like receptor 4 (TLR-4) agonist...
Methods All FMF, TRAPS, MKD and CAPS patients enrolled in the Eurofever registry until March 2013 were evaluated. For each disease gold standards were considered according to the following criteria: i) clinical validation by centers and disease-principal investigator, ii) confirmative molecular analysis (2 mutations for MEFV with at least one mutation in exon 10, 2 mutations of MVK gene, 1 muta...
Book review:
 Morse, Donald E. It’s Time: A Mosaic Reflecting What Living in Time is Like. Debrecen: Debrecen UP, 2022. 326 pages. ISBN 978-963-615-004-4. Open Access E-book and Pbk. HUF 4,000.
Regression and neural network models of wage determination are constructed where the explanatory variables include detailed information about skills. People skills, strategic skills, and IT skills all carry strong and significant wage premia; problemsolving skills (surprisingly) and physical skills (less surprisingly) do not. In contrast to the impact of school curriculum on subsequent earnings...
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