The Rho GTPase Rac regulates actin cytoskeleton reorganization to form cell surface extensions (lamellipodia) required for cell migration/invasion during cancer metastasis. Rac hyperactivation and overexpression are associated with aggressive cancers; thus, interference of the interaction of Rac with its direct upstream activators, guanine nucleotide exchange factors (GEFs), is a viable strateg...

T-14326A Abstract A decade ago, Capillary Electrophoresis (CE) was considered a novelty. Today it is commonly used in quality control worldwide, providing automated, high-resolution methods, with online detection. In the first part of this series of articles, we will illustrate an overview of CE in a modern quality control laboratory. The complete series of articles will address in depth the fo...

Due to the increasing use and production of nanomaterials (NMs), the ability to characterise their physical/chemical properties quickly and reliably has never been so important. Proper characterisation allows a thorough understanding of the material and its stability, and is critical to establishing dose-response curves to ascertain risks to human and environmental health. Traditionally, method...

Narrative approaches and storytelling are emerging as powerful health promotion tools that can spark interest, increase understanding of determinants of health, and translate complex science. A Story of Health, a multimedia e-book with continuing education (CE) credits, was designed to harness the power of storytelling to increase environmental health literacy. Health professionals are a key au...

Os policultivos agroecológicos beneficiam a pedofauna e melhoram qualidade do solo, atuando na ciclagem de nutrientes decomposição matéria orgânica. Assim, têm-se como hipótese que os promovem um ambiente propício assemelhando-se à mata nativa. Objetivou-se avaliar composição, frequência, abundância diversidade grupos compõem meso macrofauna edáfica em sistemas agroecológicos, utilizando área s...

Safety and quality of food have become a challenge for the food industry looking to replace synthetic preservatives with natural agents. In this context, cinnamon leaf essential oil (CLO) showed to be potent antioxidant and antimicrobial agent; however, its active compounds are highly reactive volatiles and grant strong odors and flavors when used as food additive. With this in mind, the object...

Due to the increasingly stringent standards, it is important to assess whether the proposed emission reduction will result in ambient concentrations that meet the standards. The Software for Model Attainment Test-Community Edition (SMAT-CE) is developed for demonstrating attainment of air quality standards of O3 and PM2.5. SMAT-CE improves computational efficiency and provides a number of advan...

BACKGROUND After more than 25 years, public health programs have not been able to sufficiently reduce the number of new HIV infections. Over 7,000 people become infected with HIV every day. Lack of convincing evidence of cost-effectiveness (CE) may be one of the reasons why implementation of effective programs is not occurring at sufficient scale. This paper identifies, summarizes and critiques...