The interaction of heparan sulfate (HS) (and the closely related molecule heparin) with FGF-1 is a requirement for enabling the growth factor to activate its cell surface tyrosine kinase receptor. However, little is known about the regulatory role of naturally occurring cell surface HS in FGF-1 activation. We have addressed this issue by utilizing a library of HS oligosaccharides, which are def...

Synthesis of 1-sn-phosphatidyl-3'-sn-glycero-1'-sulfate (phosphatidylglycero-1-sulfate) was achieved by monosulfation of 1-sn-phosphatidyl-3'-sn-glycerol (diphytanyl ether analog) with an equimolar amount of SO(3)-pyridine complex at room temperature; with excess sulfation reagent at 60 degrees C, the 1',2'-disulfate ester was obtained. The phosphatidyl-glycero-2-sulfate isomer was synthesized ...

Herpes simplex virus type 1 (HSV-1) binds to cells through interactions of viral glycoproteins gB and gC with heparan sulfate chains on cell surface proteoglycans. This binding is not sufficient for viral entry, which requires fusion between the viral envelope and cell membrane. Here, we show that heparan sulfate modified by a subset of the multiple D-glucosaminyl 3-O-sulfotransferase isoforms ...

Cruciferous vegetables are very popular in latitudes corresponding to central and eastern Europe. They rich bioactive compounds such as chlorophylls, carotenoids, polyphenols. The type quality of fertilization has a significant impact on their chemical composition. aim this study was determine the specific forms sulfur properties white cabbage, explore effect storage conditions its components a...

A systematic review of glucosamine sulfate use for osteoarthritis, based on early research (19561991), found that it has anti-inflammatory properties and rebuilds damaged cartilage. (1) These studies evaluated chondrocytes grown in culture and animal models. (1,2) Chondroitin sulfate also stimulates chondrocyte biosynthesis in both animal and in vitro studies. There is insufficient evidence to ...

background: ferrous sulfate is the most used supplement for treating anemia, but it can result in unfavorable side effects. nowadays, nanotechnology is used as a way to increase bioavailability and decrease the side effects of drugs and nutrients. this study investigates the effects of nanoparticles containing iron on blood and inflammatory markers in comparison to ferrous sulfate in anemic rat...

[1] We consider the correlation between clouds and sulfate in order to assess the relative importance of cloud aqueous-phase production of sulfate, precipatation scavenging of sulfate, and inhibition of gas-phase sulfate production beneath clouds. Statistical analysis of observed daily cloud cover and sulfate surface concentrations in Europe and North America indicates a significant negative co...

Stable sulfur (S) isotope ratios can be used to identify the sources of sulfate contributing to streamwater. We collected weekly and high-flow stream samples for S isotopic analysis of sulfate through the entire water year 2003 plus the snowmelt period of 2004. The study area was the 41-ha forested W-9 catchment at Sleepers River Research Watershed, Vermont, a site known to produce sulfate from...

Castrated male goat kids (20 Alpine, 12 Angora) were individually fed isonitrogenous and isoenergetic diets containing 2.28% N and S (added as CaSO4) at either .11 (basal), .20, .28, or .38% of dietary DM. Sulfate supplementation during the 8-wk growth trial quadratically increased ADG (P < .05) and tended to increase quadratically the DMI (P < .07) of goats, with a peak value for the .20% S di...