BACKGROUND Immunization with modified tumor cells carrying recombinant immunomodulatory genes is being explored as cancer immunotherapy. In this study, we examine whether canarypox ALVAC viruses carrying immunostimulatory cytokine genes (granulocyte-macrophage colony-stimulating factor, interleukin 2, interleukin 12, and tumor necrosis factor-alpha) can induce antitumor immunity (to rechallenge...

We revisit stellar energy-loss bounds on the Yukawa couplings $g_{\rm B,L}$ of baryophilic and leptophilic scalars $\phi$. The white-dwarf luminosity function yields B}\lesssim 7 \times 10^{-13}$ L}\lesssim 4 10^{-16}$, based bremsstrahlung from ${}^{12}{\rm C}$ ${}^{16}{\rm O}$ collisions with electrons. In models a Higgs portal, this also implies bound scalar-Higgs mixing angle $\sin \theta \...

We analyze the very short Einstein timescale ($t_\rm E \simeq 7\,{\rm hr}$) event KMT-2019-BLG-2073. Making use of pronounced finite-source effects generated by clump-giant source, we measure radius $\theta_\rm 4.8\,\rm \mu as$, and so infer a mass $M = 59\,M_\oplus (\pi_\rm{rel}/16 \,\rm as)^{-1}$, where $\pi_\rm{rel}$ is lens-source relative parallax. find no significant evidence for host thi...

Pharmacological studies have suggested that serotonergic cells in RM contribute to both the inhibition and facilitation of spinal nociceptive transmission. Physiological studies in the medullary nucleus raphe magnus (RM) and adjacent nucleus reticularis magnocellularis have identified putative nociceptive-inhibitory OFF cells and nociceptive-facilitatory neurons ON cells by their responses to n...

The entropy production prior to BBN era is one of ways prevent QCD axion with the decay constant $F_{a}\in[10^{12}{\rm GeV},10^{16}{\rm GeV}]$ from overclosing universe when misalignment angle $\theta_{\rm i}=\mathcal{O}(1)$. As such, it necessarily accompanied by an early matter-dominated (EMD) provided achieved via a heavy particle. In this work, we consider possibility formation primordial b...

We present a novel, physically-motivated sub-grid model for HII region feedback within the moving mesh code Arepo, accounting both radiation pressure-driven and thermal expansion of ionised gas surrounding young stellar clusters. apply this framework to isolated disc galaxy simulations with mass resolutions between $10^3~{\rm M}_\odot$ $10^5~{\rm per cell. Each simulation accounts self-gravity ...

In order to test active galactic nucleus (AGN) unification and evolutionary models, we measured the AGN clustering properties as a function of obscuration defined in terms hydrogen column density, $N_{\rm H}$. addition measuring unobscured ($N_{\rm H} < 10^{22}\,{\rm cm}^{-2}$) moderately obscured ($10^{22} \leq N_{\rm 10^{23.5}$) AGNs, also targeted highly sources H}\geq up redshifts $z=3$. We...

Two experiments (n = 10) were conducted to determine the effects of roller massager (RM) on ankle plantar flexor muscle recovery after exercise-induced muscle damage (EIMD). Experiment 1 examined both functional [i.e., ankle plantar flexion maximal isometric contraction and submaximal (30%) sustained force; ankle dorsiflexion maximal range of motion and resistance to stretch; and medial gastroc...