We investigate a variant of the localized orthogonal decomposition method (Henning and Peterseim, [Multiscale Model. Simul., 11 (2013), pp. 1149–1175] Målqvist [Math. Comp., 83 (2014), 2583–2603]) for elliptic problems with rough coefficients. The construction basis multiscale finite element space is based on domain techniques, which motivated by recent work Kornhuber, Yserentant 87 (2018)...

This study tested the time-of-day dependence of the intrinsic postsynaptic properties of hippocampal CA3 pyramidal neurons. High-voltage-activated Ca currents and the Caand voltage-dependent afterhyperpolarizations were examined in slices of rat brains obtained at four distinct time periods. Just after onset of the dark phase, the steady-state amplitude of the Ca current (21.24 ^ 0.11 nA) was s...

The present study examined speci®c effects of sodium cyanide (CN) on the membrane potential (MP), spontaneous discharge (SD) and voltage-gated ion current of the identi®ed bulbospinal rostral ventrolateral medulla (RVLM) neuron in the rat pup brainstem slice. 125 mM CN rapidly depolarized MP in the RVLM neuron by 11.6 mV as well as enhanced the SD rate by 300%. In contrast, the same dose of CN ...

To explore whether depth of sleep is related to changes in autonomic control, continuous power-spectral analysis of the electroencephalogram (EEG) and heart rate variability (HRV) was performed in ten normal subjects during nocturnal sleep. Quiet sleep (QS) was associated with an increase in high-frequency power (HF) of HRV (0.15–0.4 Hz) but a decrease in low-frequency power (LF) (0.04–0.15 Hz)...

Functional asymmetry of the parietal lobes during piano performance was assessed utilizing independent componentcross correlation-sequential epoch analysis of functional magnetic resonance imaging time series. Eight right handed musically trained subjects played the piano with their right hand, left hand, or both hands as cued by visually presented musical scores. The areas activated included t...

Presenilin 1 mutations are the major cause of autosomal dominant Alzheimer’s disease: here we identify a new missense mutation causing a methionine to valine change at codon 233. This codon is homologous to a pathogenic presenilin 2 mutation with the same base change (ATG to GTG) and amino acid change (M239V). This mutation causes disease with an exceptionally early onset age (~30 years) in whi...

The present study examined the correlation between the level of activity neuron B52 and the transition from protraction to retraction phases of buccal motor patterns (BMPs) and the termination of the BMPs. The level of activity in B52 during the protraction phase was positively correlated with the duration of that phase. A second burst of activity in B52 was associated with the termination of t...

Butyrylcholinesterase (BCHE) is an enzyme expressed in most human tissues. Recently, an increased odds of carrying the K variant of BCHE (BCHE-K) was reported among Alzheimer disease (AD) cases as compared with controls. We tested our data set of 245 sporadic AD cases and 241 controls for an association between BCHE-K, APOE4, and AD using logistic regression and chi-square analyses. The sib tra...

A right-brain damaged patient with pure tactile extinction was asked to report series of single or double light, brief touches delivered to both hands, the thumb or the pinkie of a single hand, the sides of a single index. The stimulated hand was positioned palm up or palm down, in front of or behind the patient, in anatomic or crossed position. In double touch conditions, stimuli coded as left...