In a preliminary note (l), the present authors reported that Lactobacillus Eeichmannii 313 is capable of using six alternative factors for growth in vitamin Bn-deficient media. Two of these were found in vitamin Blz concentrates and presumably represent two forms of the vitamin. Hoffmann et al. (2) previously noted that crystalline antipernicious anemia factor (APA) (vitamin B1.J supports the g...

Therapeutic Strategies in RA Over a 40-Year Period H.M. Kremers, P. Nicola, C.S. Crowson, W.M. O’Fallon, S.E. Gabriel . . . . . . . . . . . . . . . . . 2366 Folate, Homocysteine, and Cobalamin Status in Patients with RA Treated with MTX, and the Effect of Low Dose Folic Acid Supplement N. Hornung, T. Ellingsen, K. Stengaard-Pedersen, J.H. Poulsen . . . . . . . . . . . . . . . . . . . . . . . . ...

OBJECTIVE To examine the prevalence of low serum folate and vitamin B12, in association with elevated serum homocysteine, in a representative sample of older Australians. METHODS During 1997-2000, 3,508 persons aged 50+ years were examined in a population-based cohort study conducted in two postcodes, west of Sydney, Australia. Of these, 2,901 participants (82.7%) provided fasting blood for e...

Developments relating to cobalamin and folate are reviewed. Current work on the relations between these two coenzymes are discussed, particularly those that have emerged in studies using nitrous oxide, which inactivates cobalamin.

By S. J. BAKER, V. I. MATHAN AND K. ABE H YPERPIGMENTATION OF THE SKIN in Indian patients with megaloblastic anemia appears to have been first documented by Cook.1 Studies from this unit suggested that this was often associated with vitamin B12 deficiency,2’3 though more recent studies following the introduction of folic acid assays, have shown that it can also occur in some cases of pure folat...

OBJECTIVE To determine the prevalence and possible factors associated with anaemia, and vitamin B12 and folate deficiencies in women of reproductive age (WRA) in Pakistan. METHODS A secondary analysis was conducted on data collected through the large-scale National Nutrition Survey in Pakistan in 2011. Anaemia was defined as haemoglobin levels <12 g/dL, vitamin B12 deficiency as serum vitamin...

BACKGROUND The elderly population is particularly at risk for developing vitamin B12-deficiency. Serum cobalamin does not necessarily reflect a normal B12 status. The determination of methylmalonic acid is not available in all laboratories. Issues of sensitivity for holotranscobalamin and the low specificity of total homocysteine limit their utility. The aim of the present study is to establish...

BACKGROUND Low vitamin B12 concentration in South Asian Indians is common, but the exact prevalence is not known. AIM To investigate prevalence and associations of low vitamin B12 concentration and hyperhomocysteinemia in rural and urban Indian men living in and around Pune, Maharashtra. METHOD We studied 441 middle-aged men (149 rural, 142 slum and 150 urban middle-class residents, mean ag...

BACKGROUND Plasma methylmalonic acid (MMA) is a specific marker for functional cobalamin deficiency. This deficiency can give rise to non-specific but serious symptoms in childhood such as developmental delay, convulsions and failure to thrive and may even lead to irreversible neurological damage. AIM OF THE STUDY To analyse plasma MMA concentrations in Dutch children and to evaluate possible...

Maternal vitamin B12 deficiency during pregnancy is an independent risk factor for neural tube defects and other neurological problems in infants. We determined the vitamin B12 status of 143 pregnant women in Nigeria representing all trimesters who presented to an antenatal clinic in Jos, Nigeria, using holotranscobalamin II levels (holoTCII), which is a measure of the vitamin B12 that is avail...