DNase I mediates internucleosomal DNA degradation in human cells undergoing drug-induced apoptosis. Eur J Immunol 2001;31: 743–751. 34. Oliveri M, Daga A, Lunardi C, Navone R, Millo R, Puccetti A. DNase I behaves as a transcription factor which modulates Fas expression in human cells. Eur J Immunol 2004;34:273–279. 35. Francke S, Manraj M, Lacquemant C, Lecoeur C, Leprêtre F, Passa P, Hebe A, C...

STUDY OBJECTIVE To examine the relation of antioxidant and other nutrient intakes in pregnancy to smoking and sociodemographic variables. DESIGN Cohort study. SETTING St Mary's Maternity Hospital, Portsmouth. PARTICIPANTS Pregnant nulliparous women, with no existing complications of pregnancy, were recruited from antenatal booking clinics. A total of 774 women completed seven day food dia...

BACKGROUND Provider-dependent practice variation in children hospitalized with bronchiolitis is not uncommon. Clinical practice guidelines (CPGs) can streamline practice and reduce utilization however, CPG implementation is complex. METHODS A multidisciplinary team developed and implemented CPGs for management of bronchiolitis for children <2 years old. Children with comorbidities, ICU admiss...

Transposons and transposon-like repetitive elements collectively occupy 44% of the human genome sequence. In an effort to measure the levels of genetic variation that are caused by human transposons, we have developed a new method to broadly detect transposon insertion polymorphisms of all kinds in humans. We began by identifying 606,093 insertion and deletion (indel) polymorphisms in the genom...

We present two implementations of the Cube-4 volume rendering architecture on the Teramac cus­ tom computing machine. Cube-4 uses a slice­ parallel ray-casting alg01'ithm that allows for a paral­ lel and pipelined implementation of ray-casting with tri-linear interpolation and su'rface normal estima­ tion from interpolated samples. Shading, classifica­ tion and compositing are part of rendering...

Mutations in the Wiskott-Aldrich syndrome protein (WASP) have been hypothesized to cause defective actin cytoskeletal function. This resultant dysfunction of the actin cytoskeleton has been implicated in the pathogenesis of Wiskott-Aldrich syndrome (WAS). In contrast, it was found that stimulated actin polymerization is kinetically normal in the hematopoietic lineages affected in WAS. It was al...

This study operationalizes the conceptual analysis presented in a companion paper, to examine the effects of objective and subjective variables on the consideration of 16 travel-related strategies reflecting a range of individuals’ potential reactions to congestion. Using 1283 commuting respondents to a 1998 survey conducted in the San Francisco Bay Area, binary logit models were developed for ...

BACKGROUND Anxiety disorders increase the risk of onset of several ageing-related somatic conditions, which might be the consequence of accelerated cellular ageing. AIMS To examine the association between anxiety status and leukocyte telomere length (LTL) as an indicator of cellular ageing. METHOD Data are from individuals with current (n = 1283) and remitted (n = 459) anxiety disorder, and...

BACKGROUND Conclusions that can be drawn from earlier studies on noise and children's blood pressure are limited due to inconsistent results, methodological problems, and the focus on school noise exposure. OBJECTIVES To investigate the effects of aircraft and road traffic noise exposure on children's blood pressure and heart rate. METHODS Participants were 1283 children (age 9-11 years) at...

Ca2þ-activated Kþ channels, such as BK and IK channels, have been proposed to fulfill pivotal functions in neoplastic transformation, malignant progression, and brain infiltration of glioblastoma cells. Here, the ionizing radiation (IR) effect of IK Kþ channel targeting was tested in human glioblastoma cells. IK channels were inhibited pharmacologically by TRAM-34 or genetically by knockdown, c...