Aims and method To examine research productivity of staff working across 57 National Health Service (NHS) mental health trusts in England. We examined research productivity between 2010 and 2012, including funded portfolio studies and all research (funded and unfunded). Results Across 57 trusts there were 1297 National Institute for Health Research (NIHR) studies in 2011/2012, involving 46 140 ...

We present a new method for the study of hemisystems of the Hermitian surface U3 of PG(3, q2). The basic idea is to represent generator-sets of U3 by means of a maximal curve naturally embedded in U3 so that a sufficient condition for the existence of hemisystems may follow from results about maximal curves and their automorphism groups. In this paper we obtain a hemisystem in PG(3, p2) for eac...

BACKGROUND Red cell distribution width (RDW), a measure of the variability in size of circulating erythrocytes, is associated with mortality and adverse outcome in selected populations with cardiovascular disease. It is scarcely known whether RDW is associated with incident myocardial infarction (MI). We aimed to investigate whether RDW was associated with risk of first-ever MI in a large cohor...

An apolipoprotein (apo) B-specific monoclonal antibody, MB19, detects a commonly occurring two-allele genetic polymorphism in human apoB (Young, S. G., S. J. Bertics, L. K. Curtiss, D. C. Casal, and J. L. Witztum. 1986. Proc. Natl. Acad. Sci. USA. 83: 1101-1105). Antibody MB19 binds to two different allotypes of apoB, MB19(1) and MB19(2), with high and low affinity, respectively. The epitope fo...

Investigation into the switch between single-celled and filamentous forms of fungi may provide insights into cell polarity, differentiation, and fungal pathogenicity. At the molecular level, much of this investigation has fallen on two closely related budding yeasts, Candida albicans and Saccharomyces cerevisiae. Recently, the much more distant fission yeast Schizosaccharomyces pombe was shown ...

The eukaryotic small-subunit (SSU) ribosomal RNA (rRNA) has two evolutionarily conserved acetylcytidines. However, the acetylation sites and the acetyltransferase responsible for the acetylation have not been identified. We performed a comprehensive MS-based analysis covering the entire sequence of the fission yeast, Schizosaccharomyces pombe, SSU rRNA and identified two acetylcytidines at posi...

It has been a privilege to be part of the adventure that culminated in the Royal Society’s twin events designed to enable and encourage the forensic science community to come together to discuss and plan a vision for the future, not only for the UK, but as partners in a global ecosystem. It is also an honour to present a collection of some of the presentations within the pages of the Philosophi...

An improved method for subtracting contaminants from Cosmic Microwave Background (CMB) sky maps is presented, and used to estimate how well future experiments will be able to recover the primordial CMB fluctuations. We find that the naive method of subtracting foregrounds (such as dust emission, synchrotron radiation, free-free-emission, unresolved point sources, etc.) on a pixel by pixel basis...

In vitro susceptibility data were collected for co-amoxiclav and other antimicrobial agents against 1297 recent anaerobe isolates collected in Europe and the USA. The co-amoxiclav (amoxicillin/clavulanic acid) MIC(50/90)s (amoxicillin/clavulanic acid concentration in a ratio of 2:1, expressed in terms of amoxicillin concentration in mg/L) were 0.5/4 for Bacteroides fragilis, </=0.125/1 for Prev...