Candida tropicalis ATCC 20336 excretes , -dicarboxylic acids as a by-product when cultured on n-alkanes or fatty acids as the carbon source. Previously, a -oxidation-blocked derivative of ATCC 20336 was constructed which showed a dramatic increase in the production of dicarboxylic acids. This paper describes the next steps in strain improvement, which were directed toward the isolation and char...

A series of heteroleptic bipyridine ruthenium complexes were prepared using known synthetic methods. Each compound incorporated one electron withdrawing 4,4'-dicarboxylic acid-2,2'-bipyridine and two bipyridines each of which had electron donating dialkylamine substituents in the 4 and 4' positions. The electronic absorption spectra exhibited absorptions that moved to lower energy as the donor ...

The formation of a pair extended networks sustained by halogen bonds based upon two regioisomers photoproduct, namely rctt-1,3-bis(4-pyridyl)-2,4-bis(phenyl)cyclobutane (ht-PP) and rctt-1,2-bis(4-pyridyl)-3,4-bis(phenyl)cyclobutane (hh-PP), that have varied topology is reported. These are held together via I?N between the photoproduct halogen-bond donor 1,4-diiodoperchlorobenzene (C6I2Cl4). obs...

The exchange of the monocarboxylate ligand of the zirconium methacrylate oxocluster Zr(6)O(4)(OH)(4)(OMc)(12) (OMc = CH(2)=CH(CH(3))COO) with dicarboxylic acids (trans,trans muconic acid and terephthalic acid) leads to porous zirconium dicarboxylates exhibiting the UiO-66 architecture; the mild reaction conditions allow the control of their particle size.

The glutamic acid E396, aspartic acid D409 and glutamic acid E411 residues of the Escherichia coli penicillin-binding protein 3 were each converted into an alanine residue. As deduced from penicillin-binding and complementation experiments, none of these dicarboxylic acid residues is involved in the mechanism of acylation by penicillin and none of them is essential for the in vivo functioning o...

Papilistatin has been isolated recently and found to have good anticancer and antibacterial activity. Papilistatin is a unique phenanthrene-1,10-dicarboxylic acid. The first total synthesis of papilistatin is described here with radical cyclisation as the key step.

The biochemical mechanisms mediating the rapid distribution of valproic acid across placenta are not precisely known. We have characterized valproic acid transport by the human trophoblast using the human choriocarcinoma cell line, BeWo. The uptake of [14C]valproic acid by BeWo cells was found to be saturable and blocked by pre-exposure to the metabolic inhibitors, sodium azide and 2,4-dinitrop...

The data presented in this paper indicate operation of different mechanisms for acetate oxidation by A. aerogenes, depending on the carbon source used for growth. The mechanism for citrate-grown cells appears to involve a conventional citric acid cycle, whereas acetate-grown cells appear to incorporate acetate carbon more readily via a dicarboxylic acid cycle.

The analysis of mixed acid streams plays an important role in the control of processes for the production of acetic acid and the determination of dicarboxylic and ketoacids, such as succinic (butane-dioic acid) and levulinic acids (4-oxypentanoic acid), can present particular problems to the analyst, In process streams at high temperatures these components are fully soluble but at ambient tempe...

In this study, the effect of crocin, a substance found in Crocus sativus L. stigmata on nervous system development and regeneration was investigated. Crocin is a glycosyl ester of the polyene dicarboxylic acid crocetin and is one of the few families of carotenoids found in nature, which are freely soluble in water. In the first experiment, the effect of crocin (30 microM, 60 microM and 120 micr...