In the title compound, C(7)H(6)Cl(2)N(2)S, the benzene ring and the mean plane of the thio-urea fragment [-N-C(=S)-N] make a dihedral angle of 66.77 (3)°. Inter-molecular N-H⋯S and N-H⋯Cl hydrogen bonds link the mol-ecules into a three-dimensional network.

Complexes of the type [Cu(H-dpa)(olefin)]BF4 for ethylene (1), propylene (2), 1-butene (3), 1-hexene (4), 1-octene (5), cis-2-octene (6), trans-2-octene (7), cis-3-octene (8), trans-3-octene (9), 2-norbornylene (10), 1,5-cyclooctadiene (11), styrene (12), cis-stilbene (13), trans-stilbene (14), and Ph2C=CH2 (15) have been prepared and characterized by 1H and 13C NMR, FTIR, and TGA. The crystal ...

In the title compound, [Co(C(18)H(13)N(2)O(2)S)(3)], the Co(III) atom is coordinated by the S and O atoms of three N-furoyl-N',N'-diphenyl-thio-urea ligands in a slightly distorted octa-hedral geometry. The three O atoms are arranged fac, as are the three S atoms.

C urrent guidelines for the treatment of asthma recommend inhaled corticosteroids for all patients with persistent asthma. Despite the increasing use of these drugs, asthma remains poorly controlled in a small subset of individuals who do not respond fully to existing therapies. The medical needs of these patients have prompted a search for new medications that inhibit specific molecular target...

Signal transduction is initiated when a cytokine binds to the extracellular domains of its receptors, bringing them together and triggering a complicated sequence of events inside the cell. In this issue, LaPorte et al. (2008) present crystal structures of three signaling complexes of the cytokines interleukin-4 and interleukin-13 with their receptors, showing how events taking place outside th...

Bottromycins were first isolated from Streptomyces bottropensis by Waisvisz et al.1} and are especially active against Gram-positive bacteria and Mycoplasma1"3^.The complete structure of bottromycin A2 (1), the main active component of the complex, was first proposed by Nakamura et al. in 1966 as a linear peptide4'5), but the structure was revised in 1976 by Takahashi et al.6) to a partly cycli...