In the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (n=6632), eplerenone-associated reduction in all-cause mortality was significantly greater in those with a history of hypertension (Hx-HTN). There were 4007 patients with Hx-HTN (eplerenone: n=1983) and 2625 patients without Hx-HTN (eplerenone: n=1336). Propensity scores for eplerenone use, separately c...

Hybridization of murine myeloma cells P3-X63-Ag8.653 with splenocytes from a BALB/c mouse immunized with the syngeneic anti HLA-DR1,4,w6,w8,w9 MAb AC1.59 resulted in the development of 108 hybridomas secreting antiidiotypic antibodies. 100 of them inhibited the binding of MAb AC1.59 to target cells. Detailed analysis of the antiidiotypic MAb F5-444, F5-830, F5-963, F5-1126, F5-1336, and F5-1419...

We consider Multiway Cut, a basic graph partitioning problem in which the goal is to find the minimum weight collection of edges disconnecting a given set of special vertices called terminals. Multiway Cut admits a well known simplex embedding relaxation, where rounding this embedding is equivalent to partitioning the simplex. Current best known solutions to the problem are comprised of a mix o...

BACKGROUND Although children in contact with adults with tuberculosis (TB) should receive isoniazid (INH) preventive therapy (IPT), this is rarely implemented. OBJECTIVE To assess whether a community-based approach to provide IPT at the household level improves uptake and adherence in Ethiopia. METHODS Contacts of adults with smear-positive pulmonary TB (PTB+) were visited at home and exami...

Increased expression of plasminogen activator inhibitor-1 (PAI-1) in cancer patients is associated with unfavorable outcome, and the reason for this paradox has been poorly understood. We have previously reported elevated levels of PAI-1 in primary tumors of advanced neuroblastomas (Y. Sugiura et al., Cancer Res., 59: 1327-1336, 1999). Here we demonstrate that PAI-1 is coexpressed with the angi...

XIE, Y. G., H. Y. ZHANG, H. Y. WANG, L. F. WANG and ZH. M. YUAN, 2013. Prediction of multidimensional time series based on GS-RSR-SVR and its application in agricultural economy. Bulg. J. Agric. Sci., 19: 1327-1336 This paper proposes a method that creatively applies a Geo-statistics tool (GS) to complete fast and adequate order determination and introduces a novel algorithm, named Reasonable S...

BACKGROUND Atrial fibrillation (AF) and vascular disease share several risk factors and the two diseases often coexist. Heart rate (HR) is reported to be a major determinant of arterial stiffness. AF patients often have a transiently or persistently rapid HR. Hence, this study was to assess whether AF was significantly associated with arterial stiffness and HR could significantly influence the ...

Long noncoding RNAs (lncRNAs) regulate adipogenesis and other processes associated with metabolic tissue development and function. However, little is known about the function and profile of lncRNAs during preadipocyte differentiation in the chicken (Gallus gallus). Herein, lncRNA and mRNA expression in preadipocytes at different stages of differentiation were analyzed using RNA sequencing. A to...

Dysregulated sweat secretion can cause serious clinical problems. Experimentally regenerated human glands (hSWGs) should provide a valuable tool for dissection of hSWG biology and the pathophysiology sweating disturbance, and, ultimately drug discovery disorders; however, full establishment protocols bioengineering requires further endeavour. In this study, we attempted to establish methodology...