Metrics such as relative hazards and relative risks do not account for the prevalence of a marker over time and its relation to whether and when an outcome occurs. Uncommon markers that have good predictive values and common markers that are poorly predictive may not be (clinically) useful in predicting disease and other health outcomes. Recent work by Little et al. (Am J Epidemiol. 2011;173(12...

25/18_suppl/538; cited December 9, 2013] 35. Ali AM, Provenzano E, Bartlett JM. et al. Prognosis of early breast cancer by immunohistochemistry defined intrinsic sub-types in patients treated with adjuvant chemotherapy in the neat/br9601 trial. Int J Cancer 2013;133:1470–8. 36. Ellis MJ, Tao Y, Luo J, et al. Outcome prediction for estrogen receptor–positive breast cancer based on postneoadjuvan...

Severe fever with thrombocytopenia syndrome virus (SFTSV) has been prevalent for some time in China and it was first identified in 2010. However, the seroprevalence of SFTSV in the general population in southeastern China and risk factors associated with the infection are currently unclear. Blood samples were collected from seven counties across Zhejiang province and tested for the presence of ...

19. Hurley, J. H., Dean, A. M. Thorsness, P. E. Koshland, D. E., J . and Stroud, R. M. (1 990) J. Biol. Chem. 265, 3599-3602 20. Rubio, V., Cervera, J., Lusty, C. J., Bendala, E. and Britton, H. G. (1991) Biochemistry 30, 1068-1075 21. Rodriguez-Aparicio, L. B., Guadalajara, A. M. and Rubio, V. (1989) Biochemistry 28, 3070-3074 22. Carrey, E. A. (1992) Biochem. J. 287,79 1-795 23. Williams, N. ...

The diagnosis and prognosis of multiple sclerosis (MS) has changed dramatically over the years from the first descriptions from St. Lidwina of Schiedam (1380– 1433) and Augustus D’Este (grandson of George III) between 1822 and 1848 to the pathological descriptions of Cruveilhier (1829–1842) and Carswell (1838). Serious study and synthesis of clinical and pathological human MS began with the wor...

Two new metal-organic framework (MOF) structures, IRMOF-3b and -3c, were prepared by ring-opening reaction of 1,3-propanesultone and 2-methylaziridine with an amine functionalized MOF, IRMOF-3. The new structures are permanently functionalized with covalently linked sulfonate and alkyamine units, respectively. The underlying framework structure is retained after reaction as confirmed by powder ...

Differences in genomes underlie most organismal diversity, and aberrations in genomes underlie many disease states. With the growing knowledge of the genetic and pathogenic basis of human disease, development of safe and efficient platforms for genome and epigenome engineering will transform our ability to therapeutically target human diseases and also potentially engineer disease resistance. I...

We report the design, optimization, and experimental results of large area commercial silicon solar cell based thermophotovoltaic (TPV) energy conversion systems. Using global non-linear optimization tools, we demonstrate theoretically a maximum radiative heat-to-electricity efficiency of 6.4% and a corresponding output electrical power density of 0.39 W cm(-2) at temperature T = 1660 K when im...

In the present work we deal with the scattering dispersion and attenuation of elastic waves in different types of nonhomogeneous media. The iterative effective medium approximation based on a single scattering consideration, for the estimation of wave dispersion and attenuation, proposed in Tsinopoulos et al., [Adv. Compos. Lett. 9, 193-200 (2000)] is examined herein not only for solid componen...

Maternal Graves' disease is relatively uncommon with an estimated incidence of 0.4%-1% of all pregnancies, but only 1-5% of newborns delivered to mothers with Graves' disease develop overt clinical signs and symptoms of hyperthyroidism. Here, we describe a case of a 1380-gram female neonate who was born at 30-week gestation to a mother with Graves' disease. Our patient presented with hyperthyro...