BACKGROUND In humans, the E4 allele of the apolipoprotein E gene is associated with increased coronary heart disease risk. Surprisingly, in rodents, apolipoprotein E4 only accelerates the atherosclerotic process when transgenic for the human low-density lipoprotein receptor (LDLR) protein. We therefore investigated whether the LDLR locus interacted with the apolipoprotein E gene genotype on cor...

The CATH database of protein domain structures (http://www.biochem.ucl.ac.uk/bsm/cath_new) currently contains 34 287 domain structures classified into 1383 superfamilies and 3285 sequence families. Each structural family is expanded with domain sequence relatives recruited from GenBank using a variety of efficient sequence search protocols and reliable thresholds. This extended resource, known ...

Learning curves have been proposed as an adequate description of learning processes, no matter whether the processes manifest within minutes or across years. Different mechanisms underlying skill acquisition can lead to differences in the shape of learning curves. In the current study, we analyze the tournament performance data of 1383 chess players who begin competing at young age and play tou...

Mobile Agent technology is an interesting concept for large network-based system structures. In this paper we describe a Java-based agent environment which integrates agent execution platforms into World Wide Web servers promoting a world wide infrastructure for Mobile Agents. This system has been developed within the framework of MEMPHIS IST project, which involves the definition, development ...

The present study was aimed at analysis of bioactive constituents of leaves from Abutilon indicum. The ethyl acetate extract of the leaves were subjected to Fourier transform infrared spectroscopy (FT-IR) and Gas chromatographymass spectroscopic (GCMS) analysis. GC-MS analysis of plant extract was performed using a Perkin-Elmer GC Clarus 500 system and Interpretation on mass spectrum GC-MS was ...

Hepatitis B virus (HBV) causes chronic hepatitis in hundreds of millions of people worldwide, which can eventually lead to hepatocellular carcinoma (HCC). The molecular mechanisms underlying HBV persistence are not well understood. In this study, we found that HBV inhibited the chemotherapy drug etoposide-induced apoptosis of hepatoma cells. Further analysis revealed that HBV mRNAs possess a mi...

Ribonucleic acid (RNA)-binding proteins are key players of gene expression control. We have shown that Gemin5 interacts with internal ribosome entry site (IRES) elements and modulates initiation of translation. However, little is known about the RNA-binding sites of this protein. Here we show that the C-terminal region of Gemin5 bears two non-canonical bipartite RNA-binding sites, encompassing ...

1383-5866/$ see front matter 2011 Elsevier B.V. A doi:10.1016/j.seppur.2011.12.020 ⇑ Corresponding author. Tel.: +351 253 604 424; fa E-mail addresses: [email protected], so (S.I. Mussatto). Methanol, ethanol, and acetone at four different concentrations (90%, 70%, 50%, and 30% v/v) were used for extraction of phytoestrogens (nordihydroguaiaretic acid (NDGA), kaempferol, and quercetin) from...

1383-7621/$ see front matter 2008 Elsevier B.V. A doi:10.1016/j.sysarc.2008.02.008 q Expanded version of [1]. This work has been partia of Excellence CoreGRID funded by the European Com 004265). * Corresponding author. E-mail addresses: [email protected] (M. Ald (M. Danelutto). Algorithmic skeletons have been exploited to implement several parallel programming environments, targeting workstat...

The crystal structures of the title compounds which display cholinergic activity at the ganglionic receptor have been determined by X-ray structure analysis. [(CH3)3N+C5H11]Cl- (1) crystallizes in the orthorhombic space group Pbnm with half a formula unit per asymmetric unit, a = 11.381(14), b = 12.871(17), c = 7.316(4) A. The intensities of 1106 independent reflections were collected with an a...