objective(s) calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. derivatives of 1, 4-dihydropyridine are one of the most potent calcium antagonists. in this study four novel ', 4-dihydropyridine calcium channel blockers were synthesized and their hypotensive properties were investigated in male rats. materials and methods four 1, 4-dihydrop...

Chronic progressive metabolic problem and chronic hyperglycemia caused by a dysregulation of protein, lipid, carbohydrate metabolism are two symptoms diabetes mellitus, complicated condition. Verapamil belongs to group calcium channel blockers that not dihydropyridines. It works preventing from entering beta cells' cytoplasm, the second phase insulin release driven glucose, as well sulfonylurea...

BACKGROUND Reduced uteroplacental perfusion, the initiating event in preeclampsia, is associated with enhanced endothelin-1 (ET-1) production which feeds the vasoconstriction of uterine artery. Whether the treatments of preeclampsia were effective on ET-1 induced contraction and could reverse placental ischemia is the question addressed in this study. We investigated the effect of antihypertens...