Abstract Background Arrhythmogenic Cardiomyopathy (ACM) is a primary disease of the heart muscle, characterized by fibro-fatty myocardial replacement. Improvements in clinical diagnosis and antiarrhythmic therapy, including use defibrillator (ICD) endo-epicardial catheter ablation, have increased survival these patients, who experience late complications such as advanced failure, which sometime...

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LLE Review, Volume 142 9

Tumor associated macrophages (TAMs) play a critical role in solid tumor development where they regulate neoplastic cell proliferation , survival and invasion, promote angiogenesis, and impact effector functions of T cells (1). Typically, TAMs activated by toll-like receptor (TLR) signaling or interferon (IFN)-γ are considered classically activated or Th1-type cells, whereas those activated by i...