LK-157 is a novel tricyclic carbapenem with potent activity against class A and class C beta-lactamases. When tested against the purified TEM-1 and SHV-1 enzymes, LK-157 exhibited 50% inhibitory concentrations (IC(50)s) in the ranges of the clavulanic acid and tazobactam IC(50)s (55 nM and 151 nM, respectively). Moreover, LK-157 significantly inhibited AmpC beta-lactamase (IC(50), 62 nM), as LK...

Stable gastric pentadecapeptide BPC 157 was suggested to link inflammatory bowel disease and multiple sclerosis, and thereby, shown to equally counteract the models of both of those diseases. For colitis, cysteamine (400 mg/kg intrarectally (1 ml/rat)) and colon-colon anastomosis (sacrifice at day 3, 5, 7, and 14) were used. BPC 157 (10 μg/kg, 10 ng/kg) was applied either intraperitoneally once...

Peter Sanderson, Elaine Stone*, Young-In Kim, John C. Mathers, Ellen Kampman, C. Stephen Downes, Kenneth R. Muir and John A. Baron Nutrition Division, Food Standards Agency, London WC2 6NH, UK Division of Gastroenterology, University of Toronto, Toronto, Canada Human Nutrition Research Centre, University of Newcastle, Newcastle-upon-Tyne, UK Division of Human Nutrition, Wageningen University, W...

Sanderson, J. M., Kennedy, M. C. S., Johnson, M. F., and Manley, D. C. E. (1974). Thorax, 29, 407-416. Bronchiectasis: results of surgical and conservative management. A review of 393 cases. A consecutive series of 393 cases of bronchiectasis referred to a thoracic surgical unit has been followed up for one to 15 years. About two-thirds were managed surgically and one-third conservatively. The ...

Managing the firm’s product line offerings is one of the most important tasks that managers undertake. The composition and quality of the products that the firm offers significantly affect its market share, reputation, and ultimately, the organization’s financial performance and prospects for survival in the market. Managing product lines, moreover, is difficult, and both development and mainte...

Ph.D. thesis (European doctorate mention) in Computer Science written by Davide Buscaldi under the supervision of Dr. Paolo Rosso (Univ. Politécnica de Valencia). The author was examined in Valencia in October 2010 by a panel composed by the following doctors: Paul David Clough (University of Sheffield), Ross Purves Universität Zürich), Emilio Sanchis Arnal (Univ. Politécnica de Valencia), Mark...

Sanderson [12] gave an isomorphism θ : πm(∨ r i=1S 2 i ) −→ πm(∨ r+1 i=1 CP∞ i ). In this paper we construct for any subset σ ⊂ {1, 2, · · · , r} an isomorphism θσ from πm(∨ r i=1S 2 i ) to πm(∨ r+1 i=1 CP∞ i ). The inclusion S ∨ S →֒ CP∞ ∨ CP∞ induces a homomorphism f : πm(S 2 ∨ S) −→ πm(CP ∞ ∨ CP∞). We also compute f by evaluating f on each factor in the Hilton splitting of πm(S 2 ∨ S).

Monograph Working Group Members M Kogevinas (Spain)—Meeting Chair; M L Larramendy (Argentina); B W Stewart (Australia); T Sanderson (Canada); P Guénel (France); P Cocco (Italy); S Fukushima (Japan); ME Cebrian Garcia [unable to attend]; L T Lopez Carrillo (Mexico); R Vermeulen (Netherlands); S Naidoo (South Africa); T Prapamontol (Thailand); F L Martin [unable to attend]; L Rushton (UK); M Alav...

Humanity’s impact on the biosphere’s structures (e.g., land cover) and functioning (e.g., biogeochemical cycles) is considerable. It exceeds natural variability in many cases (Crutzen and Steffen, 2003). Up to 83% of the global terrestrial biosphere have been classified as be­ ing under direct human influence, based on geographic proxies such as human population density, settlements, roads, agr...

Sanderson [12] gave an isomorphism θ : πm(∨ r i=1S 2 i ) −→ πm(∨ r+1 i=1 CP∞ i ). In this paper we construct for any subset σ ⊂ {1, 2, · · · , r} an isomorphism θσ from πm(∨ r i=1S 2 i ) to πm(∨ r+1 i=1 CP∞ i ). The inclusion S ∨ S →֒ CP∞ ∨ CP∞ induces a homomorphism f : πm(S 2 ∨ S) −→ πm(CP ∞ ∨ CP∞). We also compute f by evaluating f on each factor in the Hilton splitting of πm(S 2 ∨ S).