Dixon A, Maric C. 17 -Estradiol attenuates diabetic kidney disease by regulating extracellular matrix and transforming growth factorprotein expression and signaling. Am J Physiol Renal Physiol 293: F1678–F1690, 2007. First published August 8, 2007; doi:10.1152/ajprenal.00079.2007.—We previously showed that supplementation with 17 -estradiol (E2) from the onset of diabetes attenuates the develop...

Due to rising concern regarding the presence of endocrine disrupting chemicals (EDCs) in surface water and groundwater throughout the United States, Asia, and Europe, treatment of these chemicals in drinking water and wastewater to protect human health and the environment is an area of great interest. Many conventional treatment schemes are relatively ineffective in removing EDCs from water and...

Background: Hyperhomocysteinemia is a recognized risk factor for atherosclerosis. Elevated homocysteine (Hcy) results in severe oxidative stress, platelets hyper activity, and impairs arterial circulation and smooth muscle proliferation in vascular wall. This study was carried out to evaluate follicular fluid (FF) Hcy, glucose and estradiol levels in IVF candidate PCOS women. Materials and Meth...

Polychlorinated dibenzo-p-dioxins (PCDDs, dioxins), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) are environmental endocrine disruptors that have half-lives of 7-10 years in the human body and have toxicities that probably include carcinogenesis. A high ratio of 4-hydroxyl estradiol (4-OH-E2) to 2-hydroxyl estradiol (2-OH-E2) has been suggested as a potential biom...

Estradiol-17beta (E2) at the dose of 1 microg/g caused an increase in cell area, lumen area and the total (cell + lumen) area of posterior silk gland (PSG) in Bombyx mori indicating that exogenously applied estradiol-17beta has a regulatory influence on silk gland activity. A dose-dependent variation in trehalase activity of PSG was found on the 5th day after topical administration of estradiol...

1 Women are exposed to estrogen in several forms such as oral contraceptive pills and 2 hormone replacement therapy. Although estrogen was believed to be cardioprotective, 3 lately, its beneficial effects are being questioned. Recent studies indicate that oxidative 4 stress in the rostral ventrolateral medulla (RVLM) may play a role in the development of 5 hypertension. Therefore, we hypothesiz...

OBJECTIVES This study was designed to examine the effects of estrogen replacement on infarct size, ventricular remodeling, and mortality after myocardial infarction (MI) in mice. BACKGROUND Observational and clinical studies suggest that the cardiovascular effects of hormone replacement therapy can differ depending on the patient population studied. No prospective studies have examined the ef...

background: bone morphogenetic protein 15 (bmp15) is a growth factor derived from oocyte and is essential for in vivo ovarian follicular growth and in this study, its effects on the improvement of growth and development of follicles during in vitro culture of neonatal mouse ovaries was investigated. methods: two week old mice were cultured for 7 days in the basic culture media with or without f...

Prepubertal beef heifers at 60 and 200 d of age, born in the fall or spring, were assigned randomly to one of three treatment groups: (1) intact = 1; (2) bilateral ovariectomy (OVX); or (3) OVX plus estradiol-17 beta(E2) administered in silastic implants (OVX + E2). Luteinizing hormone (LH) was measured in serum samples collected at 20-min intervals for 4 h from heifers on -1, +7, +21, +35 and ...