نتایج جستجو برای: 17 and ifn
تعداد نتایج: 16867817 فیلتر نتایج به سال:
BACKGROUND The relationships between tonsillar immune responses, and viral infection and allergy are incompletely known. OBJECTIVE To study intratonsillar/nasopharyngeal virus detections and in vivo expressions of T-cell- and innate immune response-specific cytokines, transcription factors, and type I/II/III interferons in human tonsils. METHODS Palatine tonsil samples were obtained from 14...
Mucosa-associated invariant T (MAIT) cells are innate-like T cells with a conserved TCR α-chain recognizing bacterial metabolites presented on the invariant MHC-related 1 molecule. MAIT cells are present in intestinal tissues and liver, and they rapidly secrete IFN-γ and IL-17 in response to bacterial insult. In colon cancer, IL-17-driven inflammation promotes tumor progression, whereas IFN-γ p...
Background: Recent studies have demonstrated an essential role for IL-17 in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). Furthermore, it has been shown that FoxP3+Treg cells play an important role in the suppression of autoinflammatory reactions. Although, previous studies have determined the immunomodulatory potentials of all-trans-retinoic acid (ATRA), but these immuno...
interleukin (il)-35 is a newly discovered suppressive cytokine and has been shown to alleviate inflammatory and autoimmune diseases. the purpose of this study was to investigate immunomodulatory capacity of il-35 in patients with allergic asthma.il-35 mrna expression levels in peripheral blood mononuclear cells (pbmcs) were detected by quantitative real-time pcr (qpcr). the fr...
Experimental allergic encephalomyelitis (EAE) is mediated by neuroantigen-specific pro-inflammatory T cells of the Th1 and Th17 effector class. Th-17 cells can be clearly defined by expression of IL-17, but not IFN-γ, IL-2 or IL-3. Th1 cells do not express IL-17, but it is unclear presently to what extent they co-express the cytokines canonically assigned to Th1 immunity (i.e., IFN-γ, IL-2 and ...
Antigen-specific cytokine profiles for pulmonary Mycobacterium avium complex disease stage diagnosis
Introduction Controlling pulmonary Mycobacterium avium complex (MAC) disease is difficult because there no way to know the clinical stage accurately. There have been few attempts use cell-mediated immunity for diagnosing stage. The objective of this study was characterize cytokine profiles CD4+T and CD19+B cells that recognize various -associated antigens in different stages MAC. Methods A tota...
CD44 is a prominent activation marker which distinguishes memory and effector T cells from their naïve counterparts. It also plays a role in early T cell signaling events as it is bound to the lymphocyte-specific protein kinase and thereby enhances T cell receptor signalling. Here, we investigated whether IFN-γ and IL-17 producing T helper cells differ in their CD44 expression and their depende...
C57BL/6 mice infected with the helminth Schistosoma mansoni develop small hepatic granulomas around parasite eggs, but concomitant immunization with soluble schistosome egg Ags (SEA) in CFA (SEA/CFA) causes marked exacerbation of the lesions in a Th1-dominated environment characterized by high levels of IFN-gamma. We explored the cause of the severe immunopathology by using IL-12p40(-/-) and IL...
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