This cross-sectional study assessed the grade of physical impairments in 61 individuals with leprosy receiving multidrug therapy (MDT) under the Brazilian Unified Health System (SUS), and residing in Campina Grande, Paraíba State, Brazil. Impairments were assessed using the disability grade (DG) standardized by the WHO, and the EHF score (Eye-Hand-Foot sum of impairment scores). Impairments wer...

Fogo selvagem (FS) is an autoimmune disease caused by IgG autoantibodies to desmoglein I (DG-I), a desmosomal glycoprotein. We have previously shown that the autoantibodies in these patients are pathogenic and restricted mainly to the IgG4 subclass. The purpose of this study was to determine if the Fc domain or the valence of FS autoantibodies were relevant in the induction of epidermal disease...

For a graph G and for each vertex v ∈ V (G), let ΛG(v) = {EG(v, 1), EG(v, 2), . . . , EG(v, kv)} be a partition of the edges incident with v. Let ΛG = {ΛG(v) ∣∣ v ∈ V (G)}. We call the pair (G,ΛG) a partitioned graph. Let k = maxv kv and let g, f : V (G)×{1, . . . , k} → N and t, u : V (G)→ N be functions where for all vertices v ∈ V (G) (i) g(v, i) ≤ f(v, i) ≤ dG(v, i) i = 1, . . . , kv (ii) u...

The fundamental problem of distance geometry, F P DG , involves the characterization and study of sets of points based only on given values of (some of) the distances between pairs of points. This problem has a wide range of applications in various areas of mathematics, physics, chemistry, and engineering. Euclidean Distance Matrices, EDM , play an important role in F P DG . They use the square...

Meningiomas with distant metastases rarely occur. We report a patient with coincident primary lung cancer and metastatic meningiomas. The presence of distinct imaging features and a differential response to chemotherapy enabled us to distinguish the primary lung cancer from the metastatic lesions. Previous studies suggest that several factors can enhance the propensity of meningioma for metasta...

Michael addition of trans-4-hydroxynonenal (HNE) to deoxyguanosine yields diastereomeric 1,N(2)-dG adducts in DNA. When placed opposite dC in the 5'-CpG-3' sequence, the (6S,8R,11S) diastereomer forms a N(2)-dG:N(2)-dG interstrand cross-link [Wang, H.; Kozekov, I. D.; Harris, T. M.; Rizzo, C. J. J. Am. Chem. Soc.2003, 125, 5687-5700]. We refined its structure in 5'-d(G(1)C(2)T(3)A(4)G(5)C(6)X(7...