Abstract Background Guidelines recommend betablockers (BB) as first line therapy in symptomatic patients with hypertrophic cardiomyopathy (HCM). A secondary role the therapeutic algorithm is assigned to non-dihydropyridine calcium channel blockers (ND-CCB). Since no randomized comparison trials between two drugs have been made so far, aim of present analysis was evaluate prognostic impact BB an...

BACKGROUND Rapid identification of positive blood cultures is important for initiation of optimal treatment in septic patients. Effects of automated, microarray-based rapid identification systems on antibiotic prescription against community-onset bacteremia (COB) remain unclear. METHODS We prospectively enrolled 177 patients with 185 COB episodes (occurring within 72 h of admission) over 17 m...

We have purified putative L-type Ca2+ channels from chick heart by virtue of their associated high affinity receptors for the Ca2+ channel effectors, dihydropyridines (DHPs), and phenylalkylamines (PAAs). A peptide of 185,000-190,000 daltons was found to comigrate with the peak of DHP binding activity during purification through two successive cycles of lectin affinity chromatography and sucros...

We present measurements of ages, metallicities, and [α/Fe] ratios for 16 globular clusters (GC) in NGC 147, NGC 185, and NGC 205 and of the central regions of the diffuse galaxy light in NGC 185, and NGC 205. Our results are based on spectra obtained with the SCORPIO multi-slit spectrograph at the 6-m telescope of the Russian Academy of Sciences. We include in our analysis high-quality HST/WFPC...

BACKGROUND Dementia is a major public health problem, and repeated cognitive data from large epidemiological studies could help to develop efficient measures of early prevention. Data collection by self-administered online tools could drastically reduce the logistical and financial burden of such large-scale investigations. In this context, it is important to obtain data concerning the comparab...

Substrate specificity is critically important for enzyme catalysis. In the adrenaline-synthesizing enzyme PNMT (phenylethanolamine N-methyltransferase), minor changes in substituents can convert substrates into inhibitors. Here we report the crystal structures of six human PNMT complexes, including the first structure of the enzyme in complex with its physiological ligand R-noradrenaline. Deter...

The extracellular matrix (ECM) of the multicellular green alga VOIW.Y carieri contains insoluble fibrous layers that surround individual cells to form contiguous cellular compartments. A highly sulphated glycoprotein with an apparent molecular mass of 185 kDa (SSG I SS) has been identified as the monomeric precursor of this distinct substructure within the ECM [1,2]. The polypeptide chain of SS...

Ischemic stroke is a major cause of mortality and morbidity globally. Among the ischemic stroke subtypes, cardioembolic stroke is with poor functional outcome (Modified Rankin score ≥ 2). Early diagnosis of cardioembolic stroke will prove beneficial. This study examined the microRNAs targeting cluster of differentiation 46 (CD46), a potential biomarker for cardioembolic stroke. CD46 mRNA level ...

OBJECTIVE To prospectively determine if tortuosity assessment by a computer program (ROPtool) that traces retinal blood vessels and measures their tortuosity was more accurate than that of individual pediatric ophthalmologists. METHODS One hundred eighty-five high-quality RetCam images from premature infants were circulated to 3 retinopathy of prematurity (ROP) experts and 3 other pediatric o...

The genome of the purple sea urchin contains numerous large gene families with putative immunological functions. One gene family, known as 185/333, is characterized by extraordinary molecular diversity resulting from single nucleotide polymorphisms and the presence or the absence of 27 large blocks of sequences known as elements. The mosaic composition of elements, known as element patterns, th...