نتایج جستجو برای: 187 and 32
تعداد نتایج: 16849621 فیلتر نتایج به سال:
Although the Abelson (Abl) tyrosine kinase inhibitor imatinib mesylate has improved the treatment of breakpoint cluster region–Abl (Bcr-Abl)–positive leukemia, resistance is often reported in patients with advanced-stage disease. Although several Src inhibitors are more effective than imatinib and simultaneously inhibit Lyn, whose overexpression is associated with imatinib resistance, these inh...
Background Immediate breast reconstruction after mastectomy can be challenging in some patients for medical or oncological reasons. Delayed two-stage tissue expander/implant is a reliable option these patients. However, data regarding surgical techniques, outcomes, and complication rates are limited. This study reports our experience using the procedure delayed reconstruction.Methods retrospect...
Abstract Ruelle (1997 Commun. Math. Phys. 187 227–41; 2003 234 185–90) (see also Jiang 2012 Ergod. Theor. Dynam. Syst. 32 1350–69) gave a formula for linear response of transitive Anosov diffeomorphisms. Recently, practically computable realizations Ruelle’s have emerged that potentially enable sensitivity analysis certain high-dimensional chaotic numerical simulations encountered in the applie...
BACKGROUND Bisdioxopiperazine anti-cancer agents are inhibitors of eukaryotic DNA topoisomerase II, sequestering this protein as a non-covalent protein clamp on DNA. It has been suggested that such complexes on DNA represents a novel form of DNA damage to cells. In this report, we characterise the cytotoxicity and DNA damage induced by the bisdioxopiperazine ICRF-187 by a combination of genetic...
This study aimed to explore the role of aberrant miRNA expression in epilepsy and to identify more potential genes associated with epileptogenesis.The miRNA expression profile of GSE49850, which included 20 samples from the rat epileptic dentate gyrus at 7, 14, 30, and 90 days after electrical stimulation and 20 additional samples from sham time-matched controls, was downloaded from the Gene Ex...
BACKGROUND The urine lipoarabinomannan (LAM) strip-test (Determine®-TB) can rapidly rule-in TB in HIV-infected persons with advanced immunosuppression. However, given high rates of empiric treatment amongst hospitalised patients in high-burden settings (≈ 50%) it is unclear whether LAM can add any value to clinical decision making, or identify a subset of patients with unfavourable outcomes tha...
The cellular abundance of the cyclin-dependent kinase (Cdk) inhibitor p27 is regulated by the ubiquitin-proteasome system. Activation of p27 degradation is seen in proliferating cells and in many types of aggressive human carcinomas. p27 can be phosphorylated on threonine 187 by Cdks, and cyclin E/Cdk2 overexpression can stimulate the degradation of wild-type p27, but not of a threonine 187-to-...
This paper explores the potential of executables for covert communication. Three techniques for the embedding of secret information are presented. Possible attacks on the stealthiness of these techniques are identified and countered. The presented concepts are implemented and evaluated for the IA32 architecture, for which we obtain an encoding rate of 1/27 before countermeasures and 1/89 after ...
miRNAs are predicted to control the activity of approximately 60% of all protein-coding genes participating in the regulation of several cellular processes and diseases, including cancer. Recently, we have demonstrated that miR-187 is significantly downregulated in prostate cancer (PCa) and here we propose a proteomic approach to identify its potential targets. For this purpose, PC-3 cells were...
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