AIMS To describe our institutional experience with high dose rate (HDR) interstitial brachytherapy (IBT) compared with previously reported results on the low dose rate (LDR) practice for head and neck cancer. MATERIALS AND METHODS Eighty-four patients with oral cavity (n=70) or oropharyngeal cancer (n=14) were treated with 192Ir HDR-IBT. Seventy-eight patients had stage I or II tumour. The pa...

PURPOSE In this study, we present the treatment of the psoriatic nail beds of patients refractory to standard therapies using high-dose-rate (HDR) brachytherapy. The custom-made micro applicators (CMMA) were designed and constructed for radiation dose delivery to small curvy targets with complicated topology. The role of the HDR brachytherapy treatment was to stimulate the T cells for an increa...

BACKGROUND Late total occlusion after vascular brachytherapy (VBT) continues to be a serious complication. Delayed reendothelialization was suggested as a pivotal cause, but the time course for complete healing is unknown. METHODS AND RESULTS Seventy-two rabbit iliac arteries underwent stent implantation and were treated with gamma-radiation using 192Ir. The prescribed doses were 0 Gy (contro...

PURPOSE Both the AccuBoost D-shaped and round applicators have been dosimetrically characterized and clinically used to treat patients with breast cancer. While the round applicators provide conformal dose coverage, under certain clinical circumstances the breast skin dose may be higher than preferred. The purpose of this study was to modify the round applicators to minimize skin dose while not...

The aim of this study was to investigate the antitumor efficacy radiodynamic therapy (RDT) with a chlorin-based photosensitizer (PS) in an vivo experiment.
 Material and Methods: performed 35 white outbred rats weighing 180±30 g. Subcutaneously transplanted Pliss lymphosarcoma (PLS) used as tumor model. Chlorin-based PS «Photolon» (RUE «Belmedpreparaty», Republic Belarus) injected intraven...

Background . Prostate cancer (PCa) is one of the most common malignant diseases in men worldwide, with over 1.1 million cases PCa reported annually. In Russian Federation, proportion patients stage I—II from 2008 to 2018 increased 37.6 % 56 %, which turn allows more and perform radical treatment methods. However, it should be noted that number both recurrent after radiation therapy (external be...

Introduction: Long-term teletherapy program is not suitable for old and working patients and those living in areas where little access to primary health care is available. Accelerated partial breast irradiation (APBI) using high dose rate (HDR) brachytherapy is an appropriate alternative for these patients due to its limited number of fractions. The AccuBoost is a system for delivering APBI. Th...

Purpose Brachytherapy (BT) deals with high gradient internal dose irradiation made up of a complex system where the source is placed nearby tumor to destroy cancerous cells. A primary concern clinical safety in BT quality assurance ensure best matches between delivered and prescribed doses targeting small volume tumors sparing surrounding healthy tissues. Hence, purpose this study evaluate perf...