1,1-Bis(3 -indolyl)-1-(p-substitutedphenyl)methanes (C-DIMs) containing para-trifluoromethyl, t-butyl, and phenyl groups are a novel class of peroxisome proliferator-activated receptor (PPAR) agonists. In LNCaP prostate cancer cells, these compounds induce PPAR -dependent transactivation, inhibit cell proliferation, and induce apoptosis. In addition, these PPAR agonists modulate a number of ant...