The described method allows the determination of velocity and attenuation variations introduced by low frequency alternating stresses and electric fields. Uniaxial stress is produced with a high load piezoelectric actuator and controlled with a strain gauge bridge. A modified impulse echo overlap system with a computer controlled sampling oscilloscope permits the measurement of very small effec...

In an attempt to improve physico-chemical and biological properties of peptide nucleic acids (PNAs), particularly water solubility and cellular uptake, the synthesis of chimeric oligomers consisted of PNA and phosphono-PNA analogues (pPNAs) bearing the four natural nucleobases has been accomplished. To produce these chimeras, pPNA monomers of two types containing N-(2-hydroxyethyl)phosphonoglyc...

When 2'-O-methoxytetrahydropyranyl-5'-O-(9-phenylxanthen-9-yl) uridylyl-(3'----5')-(2',3'-di-O-acetyluridine) 2-chlorophenyl ester (9) is treated with zinc bromide in dichloromethane-propan-2-ol (85:15 v/v) at room temperature, under stringently anhydrous conditions, the corresponding 5'-unblocked dinucleoside phosphate (10) is obtained in 86% isolated yield; however, when no special precaution...

Second harmonic generation (SHG) obtained using a potassium dihydrogen phosphate (KDP) nonlinear crystal from a CW He–Ne laser as a pump source, which emits at 632.8 nm, is reported. The SHG efficiency at the power of the He–Ne laser utilized (18 mW) and the fundamental beam waist available (0.1 mm), was evaluated theoretically; the same efficiency was measured experimentally obtaining a value ...

Pterostilbene, a naturally occurring analog of resveratrol, has previously shown PPARalpha activation in H4IIEC3 cells and was found to decrease cholesterol levels in animals. In this study, analogs of pterostilbene were synthesized and their ability to activate PPARalpha was investigated. Among analogs that was synthesized (E)-4-(3,5-dimethoxystyryl)phenyl dihydrogen phosphate showed activity ...

Of the factors tested, the source and concentration of carbon and nitrogen in the medium exerted maximum effect on growth and acid production. Glucose (15%) and urea (0.14%) induced glucose oxidase synthesis and optimum yield of calcium gluconate. Potassium dihydrogen phosphate (0.2%) and magnesium sulphate (0.06%) stimulated glucose oxidase activity and calcium gluconate production. Borax at a...