Abstract Background Forkhead box C1 (FOXC1), as a member of the FOX family, is important for promote HCC invasion and metastasis. family protein lays pivotal role in metabolism. ROS involved tumor progression associated with expression lots transcription factors. We next explored mechanism underlying FOXC1 modulating metabolism hemostasis HCC. Methods used amino acids arrays to verify which FOX...

Abstract Purpose Bacillus megaterium strain BHS1, isolated from an alkaline water sample taken Mavi Gölü (Blue Lake, Turkey), can grow on minimal medium containing 2,2-dichloropropionic acid. We characterized this bacterium at the genomic level. Methods The HiSeq platform was used to carry out genome sequencing, de novo assembly, and scaffolding with BHS1. Next, data were analyzed demarcate DNA...

Background: Zearalenone (ZEA) is known as a nonsteroidal oestrogenic mycotoxin produced by different species of Fusarium fungi. ZEA is known for its competitive effects with the natural 17-β estradiol to bind with the specific binding sites of the estrogen receptors (Ers). On the other hand, the cyclin family (especially cyclin D1) and E2F1 genes are the checkpoint genes involved in cell cycle....

OSCA  (Hyperosmdality-gate calcium-permeable channels) is a cation channel protein. By participating in sensing changes extracellular osmotic potential, it induces an increase Ca 2+  concentration, regulates and plays important role hypertonic stress induction. However, there are few studies on the  OSCA  genes of poplar. In this study, 16   genes sequenc...

results like other cancers, prostate cancer is caused by an accumulation of genetic alterations in a cell that drives it to malignant growth. specific genes and gene alterations have been suggested to play a role in its development and progression. aneuploidy, loss of heterozygosity, gene mutations, hypermethylation and inactivation of specific tumour suppressor genes such as gstpi, apc, mdr1, ...

Intervertebral disk disease is a common clinical disorder manifested by pain, ataxia, paresis, motor paralysis, and sensorimotor paralysis. The clinical features, diagnosis, and treatment of cervical and thoracolumbar disk disease have been unclear until now. In this study, some differentially expressed genes were identified, and a network was constructed based on these genes. Through the stati...

Background Due to their very high economic importance, Eucalyptus tree species are among the most planted hardwoods in the world with over 20 million hectares. However, as long-lived evergreen species, this genus is particularly exposed to cold. Frost tolerance varies among species and is inversely correlated to productivity. The AP2/ERF gene family includes developmentally and physiologically ...

Central areolar choroidal dystrophy (CACD) is a rare inherited retinal disease which causes progressive profound loss of vision in patients during their 4th decade. We have identified a Northern Irish family with 19 affected individuals in three living generations. We have performed a total genome search and established linkage of CACD in this family to chromosome 17p (multipoint Zmax = 5.65 at...

Why is studying the way that genes and genomes evolve interesting? There are many generally accepted answers. Looking for places in a genome that are highly conserved is an efficient means to locate functionally important sequences, usually genes or gene regulatory domains. Conversely, unusually fast-evolving sequences can suggest where Darwinian selection might have acted to cause important di...