1,3-dialkyl 3-phenylpyrrolidine-2, 5-diones were modified to produce potential steroid sulphatase inhibitors. These modifications were aimed at producing compounds, which could be expected to bind reasonably well to the active site of the steroid sulphatase enzyme but could not be hydrolyzed readily by the enzyme due to the covalent S-C bond present. In this regard the sulphinic acid deriv...

In this study, a new mild steel surface pretreatment solution is introduced based on phosphoric acid containing a benzimidazole derivative as inhibitor. In this way, three different benzimidazole derivatives namely benzimidazole BI, 2-methyl benzimidazole 2MBI and 2-aminobenzimidazole 2ABI were studied in the 1M H3PO4 using DC and AC electrochemical techniques. Results revealed the better corro...

In this study, we aimed to investigate the peripheral antinociception effects of specificphosphodiesterase 5 (PDE-5) inhibitor vardenafil on carrageenan-induced nociception in rats,and the role of calcium besides the L-arginine- nitric oxide (NO)- cyclic guanosine monophophate(cGMP) pathway in these effects. Hyperalgesia was induced by the intraplantar injection of 0.1mL fresh carrageenan solut...