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Vol. 24, No. 1, 2012 109 Received December 2, 2010, Revised May 16, 2011, Accepted for publication May 23, 2011 Corresponding author: Hee Young Kang, M.D., Ph.D., Department of Dermatology, Ajou University School of Medicine, San 5 Woncheondong, Yeongtong-gu, Suwon 443-721, Korea. Tel: 82-31-219-5190, Fax: 82-31-219-5189, E-mail: [email protected] This is an Open Access article distributed unde...
Cancer therapies that target key molecules have not fulfilled expected promises for most common malignancies. Major challenges include the incomplete understanding and validation of these targets in patients, the multiplicity and complexity of genetic and epigenetic changes in the majority of cancers, and the redundancies and cross-talk found in key signaling pathways. Collectively, the uses of...
PURPOSE Dedifferentiated liposarcoma (DDLPS) is an aggressive malignancy that can recur locally or disseminate even after multidisciplinary care. Genetically amplified and expressed MDM2, often referred to as a "hallmark" of DDLPS, mostly sustains a wild-type p53 genotype, substantiating the MDM2:p53 axis as a potential therapeutic target for DDLPS. Here, we report on the preclinical effects of...
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