Abstract INTRODUCTION Patients with glioblastoma have a very poor prognosis. Tumor-associated microglia and macrophages (TAMs) constitute up to 30 % of the cells in glioblastoma, they secrete cytokines, chemokines growth factors that influence microenvironment. The existence different TAM subtypes appears be more complex than established M1 M2 phenotypes, but their role is not fully understood ...