The seco-steroid hormone, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] inhibits proliferation and induces differentiation of malignant cells including those of the hematopoietic system. The 24-oxo metabolite of 1,25(OH)(2)D(3) also has prominent antiproliferative activities against various cancer cells. We chemically synthesized five novel 24-oxo vitamin D(3) analogues and evaluated their ...

An experiment was conducted to evaluate the efficacy of exogenous enzymes supplementation (ES) on performance, carcass traits and some blood parameters of broilers chickens. One hundred and eighty day old chicks with 40 ± 2 g initial body weight in a completely randomized design with 3 treatments and 4 replications were fed experimental diets included, 1) basal diet no enzymes (control), 2) bas...

BACKGROUND The vitamin D metabolizing enzymes 25-, 1α- and 24-hydroxylase are expressed in malignant cells of the cervix and the ovaries. The aim of this study was to obtain further information about the regulation of the aforementioned enzymes by vitamin D, calcidiol and calcitriol in cervical and ovarian cancer. MATERIALS AND METHODS The human cervical adenocarcinoma cell line HeLa and the ...

This study aimed to assess the relationship between quantitative assessments of clinical signs respiratory disease (recorded manually and automatically) prevalence lung lesions at slaughter validate use both in management on farm. was an observational where pigs (n = 1573) were monitored from 25 ± 5.3 kg (week 12) 114 15.4 24). Pigs housed eight rooms divided into six pens a wean-to-finish A ma...

Four growth experiments were conducted to assess the effects of organic acid supplementation on performance of starter and finisher pigs. Three 4-wk starter experiments utilized 392 pigs fed simple corn-soybean meal diets. A fourth experiment employed 135 finisher pigs in a 6-wk study. Each of the starter experiments was initiated immediately after weaning; piglets were 30 +/- 3 d of age. In Ex...

Genome-wide association studies (GWAS) have identified common polymorphisms in or near GC, CYP2R1, CYP24A1, and NADSYN1/DHCR7 genes to be associated with circulating levels of 25-hydroxyvitamin D [25(OH)D] in European populations. To replicate these GWAS findings, we examined six selected polymorphisms from these regions and their relation with circulating 25(OH)D levels in 1,605 Hispanic women...