I. FROM EXCLUSIVE USE TO PUBLIC RIGHT ............................... 240 A. Dealing the Cards, and Valuing the Deal ............................ 242 B. Reshuffling the Deck............................................................ 243 II. THE REPEAL OF GROSCH’S LAW .............................................. 246 III. THE BARAN PRINCIPLES ......................................................

In the three past decades, tissue engineering allowed to develop skin models with characteristics close ex vivo skin, particularly at level of epidermis. The main function epidermis is protect body against environmental damage (UVs, pollution, microbial pathogens…) and prevent water loss. Keratinocytes, major cellular component epidermis, proliferate differentiate form in fine a physical barrie...