p-dodecylbenzenesulfonic acid (dbsa) was used as a catalyst for a simple and efficient one-pot synthesis of aryl substititued tetrahydrobenzo[b]pyrans and dihydropyrano[c]chromens via initial knoevenagel, subsequent micheal and final heterocyclization reactions of aryl aldehyde, malononitrile and 4-hydroxycoumarin/dimedone in moderate to excellent yields. the present method was operationally si...

New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one, 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one, 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide, 7-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one and 7-[(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy]-2H-chromen-2-one were prepared starting...

Deuterium-labeled nicotinamide cofactors such as [4-2H]-NADH can be used mechanistic probes in biological redox processes and offer a route to the synthesis of selectively [2H] labeled chemicals via biocatalytic reductive deuteration. Atom-efficient routes formation recycling are therefore highly desirable but require careful design order alleviate requirement for [2H]-labeled reducing agents. ...

p-Dodecylbenzenesulfonic acid (DBSA) was used as a catalyst for a simple and efficient one-pot synthesis of aryl substititued tetrahydrobenzo[b]pyrans and dihydropyrano[c]chromens via initial Knoevenagel, subsequent Micheal and final heterocyclization reactions of aryl aldehyde, malononitrile and 4-hydroxycoumarin/dimedone in moderate to excellent yields. The present method was operationally si...

We report here a biophysical and biochemical approach to determine the differences in interactions of NiCR and NiCR-2H with DNA. Our goal is to determine whether such interactions are responsible for the recently observed differences in their cytotoxicity toward MCF-7 cancer cells. Viscosity measurement and fluorescence displacement titration indicated that both NiCR and NiCR-2H bind weakly to ...

Pentadecafluorooctanoic acid is an established peroxisome proliferator. Little is known about effects of treatment with 1H,1H,2H,2H-heptadecafluorodecan-1-ol, which is metabolized to pentadecafluorooctanoic acid. We compared effects of various dosages (3, 10, or 25 mg/kg body wt) of each of these compounds on hepatic gene expression in rats with microarrays. Microarray data were validated by re...

Both the Schiff base-mediated 2-keto-4-hydroxyglutarate aldolase of liver and the metal-activated a-keto-/3-deoxyhexarate aldolase of Escherichia coli condense pyruvate and glyoxylate to form (4-RS)-Z-keto-4-hydroxyglutarate. Both enzymes catalyzed a condensation between [3-3H3]pyruvate and glyoxylate. It was found that C-C synthesis occurred 6 to 7 times faster than C-T bond cleavage. Thus, py...

We study in detail locally Cohen-Macaulay curves in P 3 which are contained in a double plane 2H , thus completing the classification of curves lying on surfaces of degree two. We describe the irreducible components of the Hilbert schemes Hd,g(2H) of locally Cohen-Macaulay curves in 2H of degree d and arithmetic genus g, and we show that Hd,g(2H) is connected. We also discuss the Rao module of ...

utilization of photodisintegration reaction of deuterium, 2h(?,n)1h, is a precise technique for determining the percentage of 2h in tritiated and natural water. the 23na(n,?)24na reaction is a suitable ?-source for producing the 2h(?,n)1h reaction. tehran research reactor was used as a neutron source for producing 24na isotopes. the bf3 detectors were used to detect the neutron emission of h2 c...

In the title compound, C(23)H(24)N(2)O(7), the central 4H-pyran ring adopts a flattened boat conformation, whereas both cyclo-hexenone rings adopt envelope conformations, the C atom bearing the dimethyl substituent being the flap atom in each case. The mean and maximum deviation of the pyran ring are 0.0379 (4) and 0.0605 (3) Å. The mean plane of the pyran ring and the dinitro-benzene ring make...