We demonstrate that the copolymers containing boronic acid and pyrene units can be utilized for the fluorometric sensing of hydrogen peroxide (H2O2) in aqueous solutions. The copolymer exists in a relatively extended conformation in the absence of H2O2, whereas the polymer chain is contracted by the reaction of boronic acid moieties with H2O2 to form phenol groups. This conformational change in...

In the title compound, 2C(6)H(9)BNO(2) (+)·SO(4) (2-), the dihydroxy-boryl group of one of the two independent boronic acid mol-ecules participates in (B)O-H⋯O(B) and N-H⋯O(B) hydrogen bonds, while the second is involved mainly in the formation of the charge-assisted heterodimeric synthon -B(OH)(2)⋯(-)O(2)SO(2) (-). These aggregates are further connected through N-H⋯O(sulfate) inter-actions, fo...

Boronic acid transition state inhibitors (BATSIs) with R1 side chains of cefotaxime and ceftazidime were assayed against SHV-1, SHV-2, SHV-5, D104K, and D104K G238S beta-lactamases. The D104K variant was the most susceptible to inhibition by the ceftazidime BATSI (Ki, 730+/-80 nM), while the D104K G238S variant was the most susceptible to the cefotaxime BATSI (Ki, 1.1+/-0.2 microM).

A modular synthesis of functionalised biaryl phenols from two boronic acid derivatives has been developed via one-pot Suzuki-Miyaura cross-coupling, chemoselective control of boron solution speciation to generate a reactive boronic ester in situ, and oxidation. The utility of this method has been further demonstrated by application in the synthesis of drug molecules and components of organic el...

A straightforward synthesis of phenols from aryl boronic acids has been demonstrated using benzoic acid as a catalyst. Variety arylboronic bearing electron rich and withdrawing substituents gave the respective in good yields.

A biocompatible fluoride receptor has been developed where the interaction between the boronic acid ester and amine (NH) results in fluoride ion selectivity and enhanced fluorescence quenching.

Routine detection of AmpC beta lactamases in Escherichia coli is cumbersome. This study was performed to determine the usefulness of a modified disc diffusion test to detect AmpC beta lactamases in E.coli. 28 non-repetitive, cefoxitin resistant isolates of E.coli were collected from cases of urinary tract infections and screened phenotypically for ESBLs and AmpC beta lactamase using DDST (cefta...

Boronic acids have been illustrious in the literature back in 1860 [1], developing over the years into a wide studied area of chemistry. After the approval of Velcade® as proteasome inhibitor, boronic acids have emerged as a unique lead for several malignant tumors, as β-lactamase inhibitors, NS3 protease inhibitors, amino-acyl tRNA synthase inhibitors, and anticoagulants. Boronic acids and its...