Booth, Barbara A., Mary Boes, Brian L. Dake, and Robert S. Bar. Isolation and characterization of plasmingenerated bioactive fragments of IGFBP-3. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E450–E454, 1999.—Insulin-like growth factor-binding protein-3 (IGFBP-3) was digested with plasmin, and the proteolytic fragments were isolated by HPLC and tested for bioactivity as measured by stimulation ...

A long-standing question in the planetary sciences asks what the Earth is made of. For historical reasons, volatile-depleted primitive materials similar to current chondritic meteorites were long considered to provide the `building blocks' of the terrestrial planets. But material from the Earth, Mars, comets and various meteorites have Mg/Si and Al/Si ratios, oxygen-isotope ratios, osmium-isoto...

Lacourse, Karen A., Lisa J. Swanberg, Patrick J. Gillespie, Jens F. Rehfeld, Thomas L. Saunders, and Linda C. Samuelson. Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1302– G1309, 1999.—A CCK-deficient mouse mutant generated by gene targeting in embryonic stem cells was analyzed to determine...

Saluja, A. K., L. Bhagat, H. S. Lee, M. Bhatia, J. L. Frossard, and M. L. Steer. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G835–G842, 1999.—The mechanisms responsible for intrapancreatic digestive enzyme activation as well as the relationship between that activation and cell injury during panc...

Meddings, J. B., J. Jarand, S. J. Urbanski, J. Hardin, and D. G. Gall. Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G951–G957, 1999.—The BB rat spontaneously develops autoimmune diabetes. Feeding these animals a hydrolyzed casein diet significantly reduces the incidence of this disease, su...

Monemdjou, Shadi, Leslie P. Kozak, and Mary-Ellen Harper. Mitochondrial proton leak in brown adipose tissue mitochondria of Ucp1-deficient mice is GDP insensitive. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E1073–E1082, 1999.— Mice deficient in mitochondrial uncoupling protein (UCP) 1 are cold sensitive, despite abundant expression of the homologues, Ucp2 and Ucp3 (S. Enerbäck, A. Jacobsson, ...

Horská, Alena, Larry J. Brant, Donald K. Ingram, Richard G. Hansford, George S. Roth, and Richard G. S. Spencer. Effect of long-term caloric restriction and exercise on muscle bioenergetics and force development in rats. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E766–E773, 1999.—We evaluated the hypothesis that long-term caloric restriction and exercise would have beneficial effects on muscl...

WILLIAM A. BANKS,1 ROBERT N. MCLAY,2 ABBA J. KASTIN,2 ULLA SARMIENTO,3 AND SHEILA SCULLY3 1Geriatric Research, Education and Clincial Center, Veterans Affairs Medical Center and Department of Internal Medicine, Division of Geriatrics, St. Louis University School of Medicine, St. Louis, Missiouri 63106; 2Veterans Affairs Medical Center and Tulane University School of Medicine, New Orleans, Louis...

Putman, C. T., M. P. Matsos, E. Hultman, N. L. Jones, and G. J. F. Heigenhauser. Pyruvate dehydrogenase activation in inactive muscle during and after maximal exercise in men. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E483– E488, 1999.—Pyruvate dehydrogenase activity (PDHa) and acetyl-group accumulation were examined in the inactive deltoid muscle in response to maximal leg exercise in men. ...

McDaniel, Nichole, and Christian Lytle. Parietal cells express high levels of Na-K-2Cl cotransporter on migrating into the gastric gland neck. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1273–G1278, 1999.—Na-K-2Cl cotransport and Cl/HCO3 exchange are prominent mechanisms for Cl2 uptake in Cl2-secreting epithelial cells. We used immunofluorescence microscopy to delineate the distribu...