نتایج جستجو برای: 3c
تعداد نتایج: 6112 فیلتر نتایج به سال:
During the first two years of observation, AGILE detected several blazars at high significance: 3C 279, 3C 454.3, PKS 1510–089, S5 0716+714, 3C 273, W Comae, Mrk 421 and PKS 0537–441. We obtained long-term coverage of 3C 454.3, for a total of more than three months at energies above 100 MeV. 3C 273 was the first blazar detected simultaneously by the AGILE gamma-ray detector and by its hard X-ra...
H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that abrogate binding of human antibodies. During the 2014-2015 influenza season, clade 3C.2a H3N2 viruses possessing a new predicted glycosylation site in antigenic site B of HA emerged, and these viruses remain prevalent today. The 2016-2017 seasonal influenza vaccine was updated to include a clade 3C.2a H3N2 s...
We hypothesized that one could assess total body mineral (TBM) and bone mineral content (BMC) from measurements of body density and bioelectrical response spectroscopy (BRS)-determined total body water by using a three-compartment (3C) model. We compared TBM and BMC computed from measurements of water (2H2O dilution or BRS) and body density (underwater weighing) with [4-compartment (4C)] and wi...
The oncolytic picornavirus Seneca Valley Virus (SVV-001) demonstrates anti-tumor activity in models of small cell lung cancer (SCLC), but may ultimately need to be combined with cytotoxic therapies to improve responses observed in patients. Combining SVV-001 virotherapy with a peptide prodrug activated by the viral protease 3C is a novel strategy that may increase the therapeutic potential of S...
Treatment of a protected 9-(5, 6-dideoxy-beta-D-ribo-hex-5-ynofuranosyl)adenine derivative with silver nitrate and N-iodosuccinimide (NIS) and deprotection gave the 6'-iodo acetylenic nucleoside analogue 3c. Halogenation of 3-O-benzoyl-5,6-dideoxy-1, 2-O-isopropylidene-alpha-D-ribo-hex-5-enofuranose gave 6-halo acetylenic sugars that were converted to anomeric 1,2-di-O-acetyl derivatives and co...
Human rhinoviruses, the most important etiologic agents of the common cold, are messenger-active single-stranded monocistronic RNA viruses that have evolved a highly complex cascade of proteolytic processing events to control viral gene expression and replication. Most maturation cleavages within the precursor polyprotein are mediated by rhinovirus 3C protease (or its immediate precursor, 3CD),...
A novel series of 1-(pyrrolidin-1-ylmethyl)-2-[(3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinoline derivatives maj-3a-maj-3u were synthesized and evaluated in vitro for their binding affinity at κ-opioid receptors. Maj-3c displayed the highest affinity for κ-opioid receptors (Ki = 0.033 nM) among all the compounds evaluated. Furthermore, all four stereoisomers of compound 3c were prepared, and...
Galectin-3 is an important protein in molecular signalling events involving carbohydrate recognition, and an understanding of the hydrogen-bonding patterns in the carbohydrate-binding site of its C-terminal domain (galectin-3C) is important for the development of new potent inhibitors. The authors are studying these patterns using neutron crystallography. Here, the production of perdeuterated h...
We present optical spectroscopy of the host galaxies of 4 QSO’s: PG 1444+407, PKS 2349-147, 3C 323.1, and 4C 31.63 having a redshift range 0.1 ≤ z ≤ 0.3. The spectra were obtained at the Keck Observatory with the LRIS instrument offset 2-4 arcseconds from the nucleus at several position angles in each galaxy. The objects close to 3C 323.1 and PKS 2349-147 have the same redshifts of their nearby...
The 3C-like proteinase of severe acute respiratory syndrome (SARS) coronavirus has been proposed to be a key target for structural-based drug design against SARS. In order to understand the active form and the substrate specificity of the enzyme, we have cloned, expressed, and purified SARS 3C-like proteinase. Analytic gel filtration shows a mixture of monomer and dimer at a protein concentrati...
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