نتایج جستجو برای: 3t3 l1 cells

تعداد نتایج: 1410204  

2012
Ko Fujimori Mutsumi Yano Toshiyuki Ueno

We recently reported that aldo-keto reductase 1B3-produced prostaglandin (PG) F(2α) suppressed the early phase of adipogenesis. PGE(2) is also known to suppress adipogenesis. In this study, we found that microsomal PGE(2) synthase (PGES)-1 (mPGES-1; PTGES1) acted as the PGES in adipocytes and that PGE(2) and PGF(2α) synergistically suppressed the early phase of adipogenesis. PGE(2) production w...

2016
Joomin Lee Ah-Ra Kim Jae-Joon Lee

The present study was carried out to evaluate the anti-obesity effect of different concentrations of extracts of hot air-dried ramie leaf (HR) and freeze-dried ramie leaf (FR) in 3T3-L1 cells and pig preadipocytes. To analyze the effect on cell proliferation, cells were treated with 25 μg/mL or 100 μg/mL HR or FR extract for 2 days. Cell differentiation was evaluated by measuring glycerol-3-pho...

2013
Rim Hong-Kun Moon Phil-Dong Choi In-Hwa Lee Eun-Hee Kim Hyung-Min Jeong Hyun-Ja

BACKGROUND & OBJECTIVES Obesity is now considered as a major risk factor for the development of fatty liver diseases, cardiovascular diseases, and atherosclerosis. SoSoSo is a newly developed dietary supplement made of seven medicinal herbs. This study was aimed at examining the anti-obesity effect of SoSoSo or its active ingredient chrysophanol on the production of inflammatory cytokines and a...

Journal: :Biological and Pharmaceutical Bulletin 2007

2018
Byoungjae Kim Kyung Min Choi Hong Soon Yim Hyun Tae Park Joung Han Yim Min Goo Lee

PURPOSE Ascorbic acid has been reported to have an adipogenic effect on 3T3-L1 preadipocytes, while evidence also suggests that ascorbic acid reduces body weight in humans. In this study, we tested the effects of ascorbic acid on adipogenesis and the balance of lipid accumulation in ovariectomized rats, in addition to long-term culture of differentiated 3T3-L1 adipocytes. MATERIALS AND METHOD...

Journal: :Free Radical Biology and Medicine 2010

2016
Zhen Zhang Zhigang Zhou Yu Li Linkang Zhou Qianwen Ding Li Xu

The fibroblast cell line of 3T3-L1 was used as a cell model for screening and evaluating the feasibility of probiotic components in improving animal lipid metabolisms. The extracts from 12 Lactobacillus strains caused significantly reduced triacylglycerol (TAG) accumulation but with severe inflammation induction in 3T3-L1 adipocytes. Interestingly, exopolysaccharides (EPS) from LGG (Lactobacill...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1993
L Kozma K Baltensperger J Klarlund A Porras E Santos M P Czech

Recent observations suggest that insulin increases cellular levels of activated, GTP-bound Ras protein. We tested whether the acute actions of insulin on hexose uptake and glucose-transporter redistribution to the cell surface are mimicked by activated Ras. 3T3-L1 fibroblasts expressing an activated mutant (Lys-61) N-Ras protein exhibited a 3-fold increase in 2-deoxyglucose uptake rates compare...

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