In 1968, Marshall and Johnson settled a long-standing structural problem with â-vetivone, firmly establishing it as 1 by synthesis.1 Previously, â-vetivone was considered to be a bicyclic R,â-unsaturated ketone possessing a hydrazulene framework, interpretive of its dehydrogenation to give vetivazulene. The interpretive error arose from the assumption that the dehydrogenation occurred without s...

Page 3. It is not entirely clear what causal model the authors have in mind, and specifically whether they consider smoking and air pollution as mediators or confounders of the association between SES and respiratory health. In paragraph two, page 1, they imply mediation (â##â#¦strongly influenced by SES..â##) but in paragraph three, confounding is implied (â##....competing factorsâ#¦â##). This...

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The aggregation of the â-peptide into amyloid is a key pathological event in Alzheimer’s disease. This process (â-amyloidosis) involves the conversion of soluble random coil, R-helical or â-sheet conformations into insoluble, aggregated â-pleated sheet structures. The pH is a significant extrinsic factor that influences â-amyloidosis, which must be related to the presence of ionizable groups in...

We investigated the antitumor activity of Adriamycin on a monocyticlike cancer cell line U-937 after its binding on polymethacrylate nanospheres (diameter, 270-350 nm). Compared to free Adriamycin (F-ADR), nanosphere-bound Adriamycin (B-ADR) exhibits a 3-fold enhancement of cytotoxicity, as determined by cell growth inhibition and DNA synthe sis, after continuous exposure to 0.02 and 0.04 /ig/m...

Based on CoVs, the genomic structure is arranged in a +ssRNA with approximately 30kb length which biggest known RNA viruses including 5′-cap and 3′-poly-A tail. (positive stranded viruses), can infect humans multiple species of animals, cause enteric, respiratory, central nervous system diseases many species. These are important for anti-CoV drug delivery through pivotal function viral gene...

Thirteen patients with metastatic breast carcinoma were given injec dons of 50—1593@ag of †̃311-monoclonal antibody (MAb) B6.2 immuno globulin G and F(ab')@for pharmacokinetic evaluation and radioimmu noimaging. Blood clearance of the †̃31I-MAb-B6.2 was biphasic. The mean half-times (t@, t@.,)for the immunoglobulin G were 33 ±1.7 and 20.9 ±11.0 h, respectively. The t@ for the F(ab'>@was 1...

Amitriptyline and Perphenazine in depressive ill ness: a controlled trial. I. Haider . . . . 195 Amnesic syndrome, the Grunthal-Störrmg case of.0. L. Zangwill .. .. .. .. i13 701 —¿ ————,—(C) .. .. .. .. 557 Amylobarbitone, cross-over study with Trimi 701 pramine. J. W. Hunter et a!. . . . . . . 667 —¿ sodium, controlled comparison with nitraze 383 pam (†̃Mogadon'). C. Davies an...

To determine the type of mutation induced by 8-hydroxyguanine in a mammalian system, we examined the mutations induced by a synthetic i -I la-ruv protooncogene containing 8-hydroxyguanine in the second po sition of codon 12 (GGC) in NIH3T3 cells. Transaction of this gene significantly increased the number of transformed foci. The c-Ha-r<w gene present in these foci was analyzed by the polymeras...