The lymphocyte homing receptor integrin α(4)β(7) is unusual for its ability to mediate both rolling and firm adhesion. α(4)β(1) and α(4)β(7) are targeted by therapeutics approved for multiple sclerosis and Crohn's disease. Here, we show by electron microscopy and crystallography how two therapeutic Fabs, a small molecule (RO0505376), and mucosal adhesion molecule-1 (MAdCAM-1) bind α(4)β(7). A l...

Gaussian and Chiral β-Ensembles, which generalise well known orthogonal (β = 1), unitary (β = 2), and symplectic (β = 4) ensembles of random Hermitian matrices, are considered. Averages are shown to satisfy duality relations like {β,N, n} ⇔ {4/β, n,N} for all β > 0, where N and n respectively denote the number of eigenvalues and products of characteristic polynomials. At the edge of the spectru...

Black nightshade (Solanum nigrum L.) has been traditionally used as indigenous Chinese medicine. Phytochemical investigations of the immature fruits S. have carried out and nine phenylpropanoids (1-9) were obtained. Their structures elucidated on basis spectroscopic chemical methods, including MS, 1H 13C-NMR. They identified (7S, 8R)-4-[3-hydroxymethyl-5-(3- hydroxypropyl)-2,3-dihydrobenzofuran...

We outline a relation between the densities for β-ensembles with respect to Jacobi weight (1 − x)a(1 + x)b supported on interval (−1, 1) and Cauchy (1−ix)η(1+ix)η̄ by appropriate analytic continuation. This has consequence of implying that latter density satisfies linear differential equation degree three β = 2 five 1 4, analogs which are already known xa(1 (0, 1). concentrate case b [Jacobi 1)]...

Inadequate pancreatic β cell function underlies type 1 and type 2 diabetes mellitus. Strategies to expand functional cells have focused on discovering and controlling mechanisms that limit the proliferation of human β cells. Here, we developed an engraftment strategy to examine age-associated human islet cell replication competence and reveal mechanisms underlying age-dependent decline of β cel...

Essential for DNA biosynthesis and repair, ribonucleotide reductases (RNRs) convert ribonucleotides to deoxyribonucleotides via radical-based chemistry. Although long known that allosteric regulation of RNR activity is vital for cell health, the molecular basis of this regulation has been enigmatic, largely due to a lack of structural information about how the catalytic subunit (α(2)) and the r...

Protein disulphide isomerase (PDI; EC 5.3.4.1) is a multifunctional polypeptide that is identical to the β subunit of prolyl 4-hydroxylases. We report here on the cloning and expression of the Caenorhabditis elegans PDI}β polypeptide and its isoform. The overall amino acid sequence identity and similarity between the processed human and C. elegans PDI}β polypeptides are 61% and 85% respectively...

This paper considers the asymptotic behavior in β-Hölder spaces, and under Lp losses, of a Dirichlet kernel density estimator proposed by Aitchison Lauder (1985) for analysis compositional data. In recent work, Ouimet Tolosana-Delgado (2022) established uniform strong consistency normality this estimator. As complement, it is shown here that Aitchison–Lauder can achieve minimax rate asymptotica...

BACKGROUND The purpose of this study was to determine the α/β ratio for normal liver with hepatitis by analyzing the toxicity data from patients with unresectable hepatocellular carcinoma treated with helical tomotherapy. METHODS Between March 2006 and February 2012, 98 patients were eligible for this study. 66 patients received 45-50 Gy in 4.5-5 Gy fractions (Group A) and 32 patients receive...