OBJECTIVE Characterize the timecourse of matrix metalloproteinase (MMP-1, -2, -3, -7, -9, -11, -12, -13, and -14) and endogenous tissue inhibitors of MMPs (TIMP-1, -2, -3, and -4) upregulation during left ventricular (LV) remodeling following myocardial infarction (MI) in rats. METHODS The descending left coronary artery of male rats (Rattus norvegicus) was ligated to produce a MI. LV functio...

Tissue inhibitor of metalloproteinases-2 (TIMP-2) is a broad spectrum inhibitor of the matrix metalloproteinases (MMPs), which function in extracellular matrix catabolism. Here, phage display was used to identify variants of human TIMP-2 that are selective inhibitors of human MMP-1, a collagenase whose unregulated action is linked to cancer, arthritis, and fibrosis. Using hard randomization of ...

Metalloproteinases (MMPs) are a group of proteolytic enzymes involved in the maintenance proper structure extracellular matrix (ECM). Matrilysins (MMP-7 and MMP-26) members MMPs that show promise as potential breast cancer (BC) markers. The aim study was to evaluate plasma levels MMP-7, MMP-26 CA 15-3 individually combination assess diagnostic utility studied matrilysins patients with BC. consi...

Background: Surgical treatment strategy for acute type A aortic dissection (aTAAD) with mesenteric malperfusion (MMP) is quite challenging as it often associated poor patient outcomes, and optimal management strategies remain controversial. Methods: We conducted MEDLINE EMBASE database searches up to December 31, 2021 studies on aTAAD MMP. Data study design, demographics, strategy, mortality, c...

Matrix metalloproteinases (MMPs) are a heterogeneous family of endopeptidases that play role in many physiological functions, including the immune response. An imbalance between activity MMPs and their tissue inhibitors (TIMPs) has been proposed pathophysiology different autoimmune disorders. We aimed to assess plasmatic levels MMP-2, MMP-9, TIMP-1 -2 patients with chronic inflammatory demyelin...

As 90% of cancer-patient deaths are due to metastasis, novel therapeutics that selectively target and kill metastatic cells desperately needed. Matrix metalloproteinase-14 (MMP-14), which plays a critical role in digesting the basement membrane inducing cancer cell migration, has been found be expressed at surface circulating metastasized tumor various human cancers. We have recently shown IVS4...

Membrane-type 4 matrix metalloprotease (MT4-MMP) expression in breast adenocarcinoma stimulates tumor growth and metastatic spreading to the lung. However, whether these pro-tumorigenic and pro-metastatic effects of MT4-MMP are related to a proteolytic action is not yet known. Through site directed mutagenesis MT4-MMP has been inactivated in cancer cells through Glutamic acid 249 substitution b...

BACKGROUND Matrix metalloproteinase (MMPs) synthesized and secreted from connective tissue cells have been thought to participate in degradation of the extracellular matrix. Increased MMPs activities that degrade proteoglycans have been measured in osteoarthritis cartilage. This study aims to suppress the expression of the MMP-3 gene in in vitro human chondrosarcoma using siRNA. METHODS CELLS...

A relationship was sought between the tissue concentrations of interleukin (IL)-8, matrix metalloproteinase (MMP)-8 and MMP-9, and the numbers of the various leukocytes infiltrating the lower uterine segment stroma during parturition. Biopsy specimens of the lower uterine segment were obtained from 63 women undergoing Caesarean section at various stages of cervical dilatation at term. The conce...