In the reaction of (2,4-dioxothiazolidin-5-yl)acetyl chloride with 1,2,4-triazole, 4-phenyl-1,2,4-triazolin-5-one and 4-phenyl-1,2,4-triazolin-5-thione, the new corresponding amides (2-4) were obtained. For compounds 2 and 4 effects on central nervous system (CNS) of mice were studied.

A facile synthesis of 9-substituted 9-deazapurines as potential inhibitors of purine nucleoside phosphorylase has been achieved by the direct Friedel-Crafts aroylation or arylmethylation of 9-deazapurines using trifluoromethanesulfonic acid as catalyst. The aroylated 9-deazapurines could be transformed into the corresponding 9-aryimethyl derivatives by the Wolff-Kishner reaction. A novel synthe...

CuBr(PPh3)2(4,6-dimethylpyrimidine-2-thione) (Cu-L) was synthesized by stirring CuBr(PPh3)3 and 4,6-dimethylpyrimidine-2-thione in dichloromethane. The crystal structure of Cu-L obtained, indicated that the complex adopts a distorted tetrahedral with several intramolecular hydrogen bonds. Moreover, centrosymmetric dimer is formed intermolecular bonding bromine acceptor created symmetry operatio...

The reaction of 5-(1-adamantyl)-4-phenyl-1,2,4-triazoline-3-thione (compound 5) with formaldehyde and 1-substituted piperazines yielded the corresponding N-Mannich bases 6a-f. The reaction of 5-(1-adamantyl)-4-methyl-1,2,4-triazoline-3-thione 8 with various 2-aminoethyl chloride yielded separable mixtures of the S-(2-aminoethyl) 9a-d and the N-(2-aminoethyl) 10a-d derivatives. The reaction of c...

A series of biologically active new mixed ligand complexes of cobalt(II), nickel(II) copper(II) and cadmium(II) have been synthesized. The reactions of the Schiff base ligand 3-benzyl-1H-4-[(2-methoxybenzylidine)amino]l,2,4-triazole-5-thione(MBT);3-benzyl-1H-4-[(4chlorobenzylidine)amino]-1,2,4-triazole-5-thione(CBT); 3benzyl-1H-4-[(4-nitrobenzylidine)amino]-1,2,4-triazole-5-thione (NBT) and sod...