Murine NK cells express the Ly-49 family of class I MHC-binding receptors that control their ability to lyse tumor or virally infected host target cells. X-ray crystallography studies have identified two predominant contact sites (sites 1 and 2) that are involved in the binding of the inhibitory receptor, Ly-49A, to H-2D(d). Ly-49G2 (inhibitory) and Ly-49D (activating) are highly homologous to ...

6 Kochakian, C. D., and D. G. Harrison, Endocrinology, 70, 99 (1962). 7 Mueller, G. C., A. M. Herranen, and K. F. Jervell, Recent Prog. Hormone Research, 14, 95 (1958). 8 Mueller, G. C., J. Gorski, and Y. Aizawa, these PROCEEDINGS, 47, 164 (1961). 9 Wilson, J. D., J. Clin. Invest., 41, 153 (1962). 10Kalman, S. M., and P. M. Opsahl, Biochim. Biophys. Acta, 49, 614 (1961). 11 Wilson, J. D., Bioch...

The crystal structure of Mg(2)B(25), dimagnesium penta-eicosa-boride, was reexamined from single-crystal X-ray diffraction data. The structural model previously reported on the basis of powder X-ray diffraction data [Giunchi et al. (2006 ▶). Solid State Sci.8, 1202-1208] has been confirmed, although a much higher precision refinement was achieved, leading to much smaller standard uncertainties ...

The asymetric unit of the title compound, [Fe(C5H5)(C17H13N2)], contains two independent mol-ecules whose conformations differ, especially in the 4-{(pyridin-4-yl)methyl-idene]amino}-phenyl unit where one is flipped by almost 180°. The cyclo-penta-dienyl rings of the ferrocene unit also exhibit different staggered conformations: in one mol-ecule the conformation is staggered by 9.43 (2)° and in...

Mature NK cells comprise a highly diverse population of lymphocytes that express different permutations of receptors to facilitate recognition of diseased cells and perhaps pathogens themselves. Many of these receptors, such as those belonging to the NKRP1, NKG2, and Ly49 families are encoded in the NK gene complex (NKC). It is generally thought that these NKC-encoded receptors are acquired by ...

The title compound, [Fe(C(10)H(20)O(5))(H(2)O)(2)][Fe(2)(C(4)N(2)S(2))(4)]·2C(10)H(20)O(5), consists of an [Fe(II)(15-crown-5)(H(2)O)(2)](2+) cation, sandwiched between and O-H⋯O hydrogen bonded by two additional 15-crown-5 ether mol-ecules and two independent [Fe(III)(mnt)(2)](-) anions, where 15-crown-5 ether denotes 1,4,7,10,13-penta-oxacyclo-penta-decane and mnt denotes cis-1,2-dicyano-1,2-...

Sir: As described in the preceding paper1}, lividomycin A2) (I) is phosphorylated to its 5r/-phosphate by ATP and an enzyme prepared from Escherichia coli K-12 ML1410 R-81 carrying R factor and Pseudomonas aeruginosa TI-13. This structure of the phosphorylated and inactivated lividomycin A was proposed from chemical evidence and pmr data. In this communication, the synthesis of lividomycin A 5/...

Behavioural, psychological, and cognitive profiles of three cases, including a 5 year old male with a 49,XXXXY karyotype and a (3;15) translocation, a 9 year old male with a 49,XXXXY karyotype, and a 32 year old male with 48,XXXY/49,XXXXY mosaicism, are presented. Significant behavioural problems were seen in the two older patients. The degree of mental retardation and impairment of language ab...

We have performed a detailed first-principles study of the penta-AlN2 nanostructure in the Cairo pentagonal tiling geometry, which is dynamically stable due to the absence of imaginary mode in the calculated phonon spectrum. The formation energy and the fragment cohesive energy analyses, the molecular dynamics simulations, and the mechanical property studies also support the structural stabilit...

Twenty-two markers located on Muller's elements D or E have been mapped by in situ hybridization in six species of the obscura group of Drosophila and in D. melanogaster. The obscura species can be grouped into a Palearctic cluster (D. subobscura, D. madeirensis and D. guanche) and a Nearctic one (D. pseudoobscura, D. persimilis and D. miranda). Eleven of the probes contain known genes: E74, Ac...