Currently, no available studies evaluate the tissue trauma inflicted on menisci by commonly used meniscus repair devices and implants. The purpose of this study was to investigate pattern size micro-tears imposed tear ability visualize understand damage may guide future clinical management patients surgical device development. is created meniscal after using devices. Thirty three fresh frozen h...

Abstract INTRODUCTION Mitochondrial dysfunction in intestinal epithelial cells (IEC) is a critical driver the failure to heal chronic ulceration IBD(1). OXPHOS important for differentiation and cell polarity repairing IEC(2,3). The development of new IBD drugs that improve mitochondria function would potentially accelerate mucosal repair enhance overall clinical management refractory patients. ...

Purpose: Arthritis is a heterogeneous group of joint diseases, with the most common to be osteoarthritis (OA) and rheumatoid arthritis (RA). Increasing evidence has shown that protease-activated receptor 2 (PAR2) involved in many pathophysiological characteristics these like inflammatory responses, synovial hyperplasia, cartilage destruction, osteophyogenesis pain sensitization. PAR2 G-protein ...

Currently, the definitive treatment for end-stage organ failure is orthotropic transplantation, or the transplantation of a whole organ from one patient to another. Due to a critical shortage of viable donor organs, however, the number of unwarranted deaths due to chronic lung disease has increased: an estimated 120,000 deaths per year in the United States alone. Additionally, only about one in...

The technique of high resolution Brillouin spectroscopy has been used to determine accurately the hydrostatic pressure dependence of the elastic constants of ice Ih in the full pressure range of phase stability 0 2.8 kbar. The percentage changes in the adiabatic elastic constants c,,, cI2. cI3, cS3, c,, and bulk modulus, over the pressure range, are 3.0, 7.2, 8.4, 2.8, -1.5 and 5.6 percent per ...