Anti-inflammatory potency of 5-hydroxypyrimidine derivatives SNK-411 (2-isobutyl-4,6-dimethyl-5-hydroxypirimidine) and SNK-578 (hydrochloride 2-isobutyl-4,6-dimethyl-5-hydroxypirimidine) was evaluated on the model complete Freund`s adjuvant (CFA)-induced exudative inflammation in experiment 60 outbreed male rats weighing 180–200 g comparison with prednisolone. Prednisolone, were injected twice:...

The potency of piperine as anti inflammatory and analgesic were investigated. Piperine was evaluated for antiinflammatory effect by carrageen-induced rat paw edema. Sprague Dawley Rats were divided into the control groups were given saline perorally, piperine groups received doses of 2.5; 5 and 10 mg/kg piperine (peroral) respectively. This was followed by the administration of 1 % caragenin th...

The analgesic effect of 5fluorouracil (5-FU) was analyzed in two experimental tests in mice. Two analgesia test, writhing test and hot plate test have been performed in swiss albino mice. The tested substance used was 5-Fluorouracil, i.p. administered in doses of 10 (Lethal Dose 50/10) and 20 mg/kg body weight (bw) (Lethal dose 50/5), 1 hour before tests. In the writhing test, 5-FU has signifi ...

Temozolomide, a methylating agent with clinical activity against brain tumors, demonstrated excellent antitumor activity following p.o. administration to athymic mice bearing human brain tumor xenografts. In the early stage s.c. implanted SNB-75 astrocytoma model, a 400-mg/kg dose administered on Day 5 produced 10 of 10 Day 54 tumor-free mice. In later staged s.c. U251 and SF-295 glioblastoma m...

OBJECTIVE To summarize studies testing the efficacy and safety of single-dose acetaminophen and ibuprofen for treating children's pain or fever. DATA SOURCES Reports were gathered by searching computerized databases (from their inception through May 2002) and registries, relevant journals, and bibliographies of key articles. STUDY SELECTION Seventeen blinded, randomized controlled trials wi...

It is established that dopamine (DA) neurotransmission plays a critical role in the behavioral (e.g. discriminative stimulus) effects of cocaine in rodents. Nonetheless, research has also demonstrated that reciprocal signaling between DA and monoamine neurotransmitters, i.e. serotonin (5-HT) and norepinephrine (NE) has important implication for understanding the actions of cocaine. The present ...

BACKGROUND AND AIMS Chemotherapy-induced acute and delayed emesis involves the activation of multiple pathways, with 5-hydroxytryptamine (5-HT; serotonin) playing a major role in the initial response. Substance P tachykinin NK1 receptor antagonists can reduce emesis induced by disparate emetic challenges and therefore have a clinical utility as broad inhibitory anti-emetic drugs. In the present...

objective: nano components are today’s new wonder material. however, the safety or toxicity of these components in humans is not yet clear. in a previous study we indicated that nano zno (nzno) has a stronger anxiolytic effect compared to the conventional zno (czno). the present study was designed to evaluate the intraperitoneal administration of an opioidergic receptor agonist and antagonist o...

A conditioned place preference paradigm was used to assess potential rewarding properties of melatonin. The conditioning with melatonin was carried out at two periods of the 12-h light/dark cycle: in the morning (08.30-10.00) and in the evening (18.30-20.00). Morning administration of melatonin (2.5, 5 and 10 mg/kg) did not support conditioned place preference. In contrast, evening conditioning...