A series of novel isatin-linked 4,4-dimethyl-5-methylene-4,5-dihydrothiazole-2-thiols (IT2Ts) 1a–1g were designed as acetylcholinesterase (AChE) inhibitors capable interacting with both the catalytic active site (CAS) and peripheral anionic (PAS) enzyme simultaneously. The target IT2Ts prepared through a short synthesis in moderate yield. most potent this 1b 1c (IC50 = 18.2 27.5 μM, respectivel...

F r a n z D a l l a c k e r * , G e r m a n u s R e i c h r a t h u n d G e r a r d S c h n a c k e r s Institut für Organische Chemie der Technischen Hochschule Aachen, Prof.-Pirlet-Straße 1, D-5100 Aachen Z. Naturforsch. 34b, 624-632 (1979); eingegangen am 13. November 1978 5,6-Dimethyl-l,3-benzodioxole-4,7-quinone, 6,7-Dimethyl-l,4-benzodioxan-5,8-quinone, 7,8 -Dimethyl 3,4 -dihy dro 2 H -1,...

The title compound, C(17)H(16)N(2)O(6), is a decomposition product of the hypertension drug nifedipine [systematic name: dimethyl 2,6-dimethyl-4-(2-nitro-phen-yl)-1,4-dihydro-pyridine-3,5-dicarboxyl-ate]. The dihedral angle between the nitro-sophenyl ring and the pyridine ring is 67.1 (5)°.