A new series of 4-(2'-Oxo/thiobarbiturinyl)-2-(substitutedphenyl)-3-[(substituted aminomethylene)]-2,3-dihydro-1,5-benzothiazepines (5a-5l) and 4-(2'-oxo/thiobarbiturinyl)-2(substituted-phenyl)-3-(substitutedaminomethylene)]-2,3-dihydro-1, 5benzoxazepines (6a-6l) were synthesized. All the newly synthesized compounds were screened in vivo, for their acute toxicity and anticonvulsant activity in ...

Transition metal-catalyzed halosulfonylation of 5-ethynyl uracil nucleosides provided (E)-5-(1-chloro-2-tosylvinyl)uridines. Tetrabutylammonium fluoride-mediated direct CH arylation of 5-iodouracil nucleosides with furan or 2-heptylfuran gave 5-furyl-substituted nucleosides without the necessity of using the organometallic substrates. These two classes of 5-substituted uracil nucleosides as we...

A series of heteronemin-related antitubercular scalaranes, both from natural products and from chemical derivatization, were subjected to structure–activity investigations. Based on the activity profile, three main regions; i.e., the substituted groups hovering over C-19/C-18 and furan moiety, the functionalities in the vicinity of C-16 and the right-hand side of ring D, and the substituted gro...

This work studied the fractionation of sugarcane bagasse via Organosolv treatment using isopropanol/water in presence Raney-Ni and molybdenum carbide catalysts (Bulk Mo 2 C supported on activated carbon (AC) or Al O 3 ). The degree delignification, bio-oil solid residue composition depended type catalyst. A partial extraction hemicellulose occurred followed by depolymerization, resulting a prod...

In medicinal chemistry nitrogen containing heterocycles are the most important compounds which show various biological activities. The cinnoline are nitrogenous derivatives and found to elicit many pharmacological actions like anti-hypertensive, antithrombotic, antihistamine, antileukemic, CNS activity, anti tumor, antibacterial and antisecretory activity. We planned to synthesis new series of ...

5-Phenyl-furan-2-carboxylic acids have emerged as a new, promising class of antimycobacterial agents that the ability to interfere with iron homeostasis. Considering lack structural data on these compounds, we analyzed crystal fluorinated ester derivative 5-(4-nitrophenyl)furan-2-carboxylic acid, one most potent candidates in series. Here, describe preparation methyl 5-(2-fluoro-4-nitrophenyl)f...

3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h were prepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L- and D-amino acid amides 4a-h. Compounds 5a-h were evaluated for their cytostatic and antiviral activities. Among all the compounds evaluated, 3-benzhydryl-5-isopropyl hydantoin (5a) showed a weak but selective inhibitory effect again...