The pharmacokinetics (PK) of SB-240563 have been investigated after i.v. and s.c. administration to cynomolgus monkeys. Approximately linear PK was observed following i.v. administration over a 6000-fold dose range (0.05-300 mg/kg). After i.v. dosing, SB-240563 concentration declined in a biexponential manner with a mean terminal half-life of 13 +/- 2 days. The plasma clearance and volume of di...

Piliostigma reticulatum (Caesalpiniaceae) is used in Africa as a traditional medicine for the treatment of many diseases, such as malaria, tuberculosis and diarrhoea. We investigated the antidiarrhoeal properties of a crude ethanol extract from the stem bark of Piliostigma reticulatum (EEPR) in Wistar albino rats to substantiate its traditional use and to determine its phytochemical constituent...

Soil infertility is the main barrier to dryland agricultural production in China. To provide a basis for the establishment of a soil amelioration technical system for rainfed fields in the semiarid area of northwest China, we conducted a four-year (2007-2011) field experiment to determine the effects of wheat straw incorporation on the arid soil nutrient levels of cropland cultivated with winte...

Genetic trend for milk yield in the artificially sired Holstein population in the northeastern United States was estimated from solutions for simultaneous genetic evaluations of bulls and cows for an animal model using mixed model equations and including all known relationships among the population by years of birth of 1960 to 1980 (1978 for bulls). First lactation milk records of 1,074,971 art...

The soil water supply is the main factor that limits dryland crop production in China. In a three-year field experiment at a dryland farming experimental station, we evaluated the effects of various straw mulch practices on soil water storage, grain yield, and water use efficiency (WUE) of winter wheat (Triticum aestivum). Field experiments were conducted with six different mulch combinations (...

Field trials of the present study was realized in 3 isolation areas (3 different regions) as EK1102 variety Eşrefli location, VE3060 Aşağıpiribeyli location and PS4042 Doğanyurt - TURKEY according to split plot randomized complete block design with replications. The main plots consisted from plant density for line control (PS4042: 6200 da -1 , VE3060: 5700 EK1102: 6500 5000 6000 7000 ) 4 potass...