AWD 12-281 is a potent (IC(50) = 9.7 nM) and highly selective inhibitor of the phosphodiesterase 4 (PDE4) isoenzyme with low affinity to the high-affinity rolipram-binding site. The compound was optimized for topical treatment of asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. The aim of the present study was to assess the effect of AWD 12-281 in human inflammatory ...

Alignment of latitude and longitude for all pixels is important for geo-stationary meteorological satellite (GSMS) images. To align landmarks and non-landmarks in the GSMS images, we propose a geometry-based global alignment method. Firstly, the Global Self-consistent, Hierarchical, High-resolution Geography (GSHHG) database and GSMS images are expressed as feature maps by geometric coding. Acc...

Adults of the tomato stink bug, Arvelius albopunctatus (De Geer), from pasture lands at Londrina, Paraná state (latitude 23º 18' S; longitude 51º 09' W) and of Dichelops furcatus (F.) (Heteroptera: Pentatomidae) from field crops at Cruz Alta, Rio Grande do Sul state (latitude 28º 38' S; longitude) southern Brazil were parasitized by Hexacladia smithii Ashmead , which are set as new host records...