Taicatoxin, isolated from the venom of the Australian taipan snake Oxyuranus scutellatus, has been previously regarded as a specific blocker of high threshold Ca channels in heart. Here we show that taicatoxin (in contrast to a range of other Ca channel blockers) interacts with apamin-sensitive, small conductance, Caactivated potassium channels on both chromaffin cells and in the brain. Taicato...

Domestic Hot Water (DHW) production constitutes a significant proportion of the energy demand modern buildings, and as building envelope is improved share increases. This article shows results from measurement campaign on two equal hotel blocks, in same hotel. There are different basin shower mixing taps installed one with original mixers (13–14 l/min) touch-free operated water saving (5–6 l/mi...

Core promoters mediate transcription initiation by the integration of diverse regulatory signals encoded in the proximal promoter and enhancers. It has been suggested that genes under simple regulation may have low-complexity permissive promoters. For these genes, the core promoter may serve as the principal regulatory element; however, the mechanism by which this occurs is unclear. We report h...

According to the Conceptual Metaphor Theory, people understand abstract concepts depending on the activation of more concrete concepts, but not vice versa. The present research aims to investigate the role of directionality and automaticity regarding the activation of the conceptual metaphor "good is up". Experiment 1 tested the automaticity of the spatial-to-valence metaphoric congruency effec...

to measure soil water content (or soil matric suction) in thin layers of about 30mm, conventional gypsum blocks are not suitable. to carry out the task, mini-gypsum blocks were constructed using plaster of paris in an innovative fashion. a power relationship was found between the soil water content and the mini-gypsum blocks’ readings in kω. the calibration results showed that readings of m...

1. Introduction Resolvable designs, though introduced in the combinatorial context, have found their utility in field experiments. The concept of resolvability is due to Bose (1942) who defined this for a balanced incomplete block (BIB) design. A BIB design is an arrangement of v treatments into b blocks such that each block contains k (< v) distinct treatments, each treatment appears in r bloc...

1. Nielsen KC, Guller U, Steele SM, Klein SM, Greengrass RA, Pietrobon R: Influence of obesity on surgical regional anesthesia in the ambulatory setting: An analysis of 9,038 blocks. ANESTHESIOLOGY 2005; 102:181–7 2. Cotter JT, Nielsen KC, Guller U, Steele SM, Klein SM, Greengrass RA, Pietrobon R: Increased body mass index and ASA physical status IV are risk factors for block failure in ambulat...

Interleukin-6 (IL-6), a multifunctional cytokine, contributes to proliferation or differentiation of prostate carcinoma cells in a highly cell type-specific manner. Celastrol (3-hydroxy-24-nor-2oxo-1(10),3,5,7-friedelatetrane-29-oic acid), also named as tripterine, is extracted from root of Chinese traditional herb Tripterygiumwilfordii Hook f with potent anti-inflammatory and anti-cancer activ...